Development of concurrent magnetic resonance imaging and volumetric optoacoustic tomography: A phantom feasibility study

Wuwei Ren; Xosé Luís Deán‐Ben; Mark‐Aurel Augath; D. Razansky

doi:10.1002/jbio.202000293

journal article Nov 26, 2020

Development of concurrent magnetic resonance imaging and volumetric optoacoustic tomography: A phantom feasibility study

Wuwei Ren

Xosé Luís Deán‐Ben Mark‐Aurel Augath D. Razansky

Journal of Biophotonics Vol. 14 No. 2 · Wiley

View at Publisher Save 10.1002/jbio.202000293

Abstract

AbstractOptoacoustic tomography (OAT) and magnetic resonance imaging (MRI) provide highly complementary capabilities for anatomical and functional imaging of living organisms. Herein, we investigate on the feasibility of combining both modalities to render concurrent images. This was achieved by introducing a specifically‐designed copper‐shielded spherical ultrasound array into a preclinical MRI scanner. Phantom experiments revealed that the OAT probe caused minimal distortion in the MRI images, while synchronization of the laser and the MRI pulse sequence enabled defining artifact‐free acquisition windows for OAT. Good dynamic OAT contrast from superparamagnetic iron oxide nanoparticles, a commonly used agent for MRI contrast enhancement, was also observed. The hybrid OAT‐MRI system thus provides an excellent platform for cross‐validating functional readings of both modalities. Overall, this initial study serves to establish the technical feasibility of developing a hybrid OAT‐MRI system for biomedical research.

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Citations

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References

Details

Published: Nov 26, 2020
Vol/Issue: 14(2)
License: View

Authors

W

Wuwei Ren

Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology University of Zurich and ETH Zurich Zurich Switzerland

X

Xosé Luís Deán‐Ben

Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology University of Zurich and ETH Zurich Zurich Switzerland

M

Mark‐Aurel Augath

Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology University of Zurich and ETH Zurich Zurich Switzerland

D

D. Razansky

Institute for Biomedical Engineering and Institute of Pharmacology and Toxicology University of Zurich and ETH Zurich Zurich Switzerland

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung Award: 310030_192757

Cite This Article

Wuwei Ren, Xosé Luís Deán‐Ben, Mark‐Aurel Augath, et al. (2020). Development of concurrent magnetic resonance imaging and volumetric optoacoustic tomography: A phantom feasibility study. Journal of Biophotonics, 14(2). https://doi.org/10.1002/jbio.202000293

Development of concurrent magnetic resonance imaging and volumetric optoacoustic tomography: A phantom feasibility study

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