Skeletal Biology and Disease Modeling in Zebrafish

Kristin Dietrich; Imke AK Fiedler; Anastasia Kurzyukova; Alejandra C López-Delgado; Lucy M McGowan; Karina Geurtzen; Chrissy L Hammond; Björn Busse; Franziska Knopf

doi:10.1002/jbmr.4256

journal article Open Access Dec 01, 2020

Skeletal Biology and Disease Modeling in Zebrafish

Kristin Dietrich Imke AK Fiedler Anastasia Kurzyukova Alejandra C López-Delgado

Lucy M McGowan

Karina Geurtzen Chrissy L Hammond

Björn Busse

Franziska Knopf

Journal of Bone and Mineral Research Vol. 36 No. 3 pp. 436-458 · Oxford University Press (OUP)

View at Publisher Save 10.1002/jbmr.4256

Abstract

ABSTRACTZebrafish are teleosts (bony fish) that share with mammals a common ancestor belonging to the phylum Osteichthyes, from which their endoskeletal systems have been inherited. Indeed, teleosts and mammals have numerous genetically conserved features in terms of skeletal elements, ossification mechanisms, and bone matrix components in common. Yet differences related to bone morphology and function need to be considered when investigating zebrafish in skeletal research. In this review, we focus on zebrafish skeletal architecture with emphasis on the morphology of the vertebral column and associated anatomical structures. We provide an overview of the different ossification types and osseous cells in zebrafish and describe bone matrix composition at the microscopic tissue level with a focus on assessing mineralization. Processes of bone formation also strongly depend on loading in zebrafish, as we elaborate here. Furthermore, we illustrate the high regenerative capacity of zebrafish bones and present some of the technological advantages of using zebrafish as a model. We highlight zebrafish axial and fin skeleton patterning mechanisms, metabolic bone disease such as after immunosuppressive glucocorticoid treatment, as well as osteogenesis imperfecta (OI) and osteopetrosis research in zebrafish. We conclude with a view of why larval zebrafish xenografts are a powerful tool to study bone metastasis. © 2021 The Authors. Journal of Bone and Mineral Research published by Wiley Periodicals LLC on behalf of American Society for Bone and Mineral Research (ASBMR).

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Details

Published: Dec 01, 2020
Vol/Issue: 36(3)
Pages: 436-458
License: View

Authors

K

Kristin Dietrich

Center for Regenerative Therapies TU Dresden (CRTD) Center for Healthy Aging TU Dresden Dresden Germany

I

Imke AK Fiedler

Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf Hamburg Germany

A

Anastasia Kurzyukova

Center for Regenerative Therapies TU Dresden (CRTD) Center for Healthy Aging TU Dresden Dresden Germany

A

Alejandra C López-Delgado

Center for Regenerative Therapies TU Dresden (CRTD) Center for Healthy Aging TU Dresden Dresden Germany

L

Lucy M McGowan

School of Physiology, Pharmacology and Neuroscience University of Bristol Bristol UK

K

Karina Geurtzen

Center for Regenerative Therapies TU Dresden (CRTD) Center for Healthy Aging TU Dresden Dresden Germany

C

Chrissy L Hammond

School of Physiology, Pharmacology and Neuroscience University of Bristol Bristol UK

B

Björn Busse

Interdisciplinary Competence Center for Interface Research (ICCIR) Hamburg Germany; Department of Osteology and Biomechanics University Medical Center Hamburg-Eppendorf Hamburg Germany

F

Franziska Knopf

Center for Regenerative Therapies TU Dresden (CRTD) Center for Healthy Aging TU Dresden Dresden Germany

Funding

Wellcome Trust Award: Wellcome Trust Dynamic Molecular Cell Biology doctoral training program to LMM

Deutsche Forschungsgemeinschaft Award: SPP 2084 µBone to BB project B2562/6‐1, SPP 2084 µBone to FK project KN 1102/2‐1,

Deutscher Akademischer Austauschdienst Award: student fellowship to AK

Versus Arthritis Award: Versus Arthritis Senior Fellowship 21937 to CLH

Cite This Article

Kristin Dietrich, Imke AK Fiedler, Anastasia Kurzyukova, et al. (2020). Skeletal Biology and Disease Modeling in Zebrafish. Journal of Bone and Mineral Research, 36(3), 436-458. https://doi.org/10.1002/jbmr.4256

Skeletal Biology and Disease Modeling in Zebrafish

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