Addressing potential role of magnesium dyshomeostasis to improve treatment efficacy for epilepsy: A reexamination of the literature

Katie E. Osborn; R. Douglas Shytle; Alfred T. Frontera; Jason R. Soble; Mike R. Schoenberg

doi:10.1002/jcph.626

journal article Oct 26, 2015

Addressing potential role of magnesium dyshomeostasis to improve treatment efficacy for epilepsy: A reexamination of the literature

Katie E. Osborn R. Douglas Shytle Alfred T. Frontera Jason R. Soble

Mike R. Schoenberg

The Journal of Clinical Pharmacology Vol. 56 No. 3 pp. 260-265 · Wiley

View at Publisher Save 10.1002/jcph.626

Abstract

AbstractMagnesium (Mg2+) is an abundant mineral in the body serving many biochemical functions. Magnesium supplementation has been shown to raise seizure threshold in animal and human studies, but the etiological contribution of magnesium deficiency to the onset and maintenance of epilepsy, as well as the degree to which it impacts antiepileptic drug efficacy, remains poorly understood. This may be due, at least in part, to the inherent limitations of commonly used serum levels as a measure of functional magnesium status, as well as insufficient data regarding relative bioavailabilities of various magnesium salts and chelates for use with humans. To date, 1 randomized clinical trial has been conducted assessing Mg2+ supplementation in epilepsy, and findings yielded promising results. Yet a notable dearth in the literature remains, and more studies are needed. To better understand the potential role of magnesium deficiency as a causal factor in epilepsy, more convenient and accurate measurement methods should to be developed and employed in randomized, controlled trials of oral magnesium supplementation in epilepsy. Findings from such studies have the potential to facilitate far‐reaching clinical and economic improvements in epilepsy treatment standards.

Topics

No keywords indexed for this article. Browse by subject →

References

67

[1]

10.4236/pp.2014.57086

[2]

Alchamdi SMG "Magnesium as an effective adjunct therapy for drug resistant seizures" Am J Kidney Dis (1994)

[3]

10.1016/s0009-8981(99)00258-2

[4]

10.1016/s0272-6386(12)80667-6

[5]

10.1001/archinte.1985.00360090162024

[6]

Chui D "The dishomeostasis of metal ions plays an important role for the cognitive impairment" Mol Neurodegener (2013) 10.1186/1750-1326-8-s1-p13

[7]

10.1016/j.neuron.2009.12.026

[8]

Vink R "Magnesium in acute and chronic brain injury: An update" Magnes Res (2009) 10.1684/mrh.2009.0175

[9]

10.1186/s10194-015-0516-6

[10]

10.1056/nejmoa1408827

[11]

10.1093/ajcn/22.3.367

[12]

10.1016/0024-3205(90)90616-y

[13]

10.1080/07315724.1994.10718430

[14]

10.3177/jnsv.49.201

[15]

10.1111/j.1750-3841.2011.02612.x

[16]

10.1080/07315724.2005.10719461

[17]

10.1042/cs20120045

[18]

Welt LG "Disorders of magnesium metabolism" Dis Mon (1965)

[19]

10.1515/cclm.2010.077

[20]

10.1684/mrh.2011.0292

[21]

10.1586/erp.10.80

[22]

10.1046/j.1528-1157.43.s.6.12.x

[23]

10.1111/j.1528-1167.2009.02159.x

[24]

FrenchJA KannerA BautistaJ et al. Efficacy and tolerability of the new antiepileptic drugs I: treatment of new onset epilepsy: report of the Therapeutics and Technology Assessment Subcommittee and Quality Standards Subcommittee of the American Academy of Neurology and the American Epilepsy Society.Epilepsia.2004;45(5):401–409. 10.1111/j.0013-9580.2004.06204.x

[25]

10.1212/01.wnl.0000123695.22623.32

[26]

10.1016/j.yebeh.2013.12.025

[27]

10.1016/j.eplepsyres.2012.02.004

[28]

Ulvi H "Magnesium, zinc and copper contents in hair and their serum concentrations in patients with epilepsy" East Jo Med (2002)

[29]

Gupta SK "Serum magnesium levels in idiopathic epilepsy" J Assoc Physicians India (1994)

[30]

10.1016/0002-9378(92)91749-z

[31]

10.1007/s10517-007-0292-7

[32]

10.1359/jbmr.1998.13.4.749

[33]

10.1016/s0002-9378(12)90855-8

[34]

Magnesium deficiency as a cause of acute intractable seizures

D. Nuytten, J. Van Hees, A. Meulemans et al.

Journal of Neurology 10.1007/bf00319737

[35]

10.1016/j.pediatrneurol.2005.03.009

[36]

10.1016/s0306-4522(97)00178-4

[37]

10.1016/s0165-3806(03)00005-1

[38]

10.1017/s0007114508006752

[39]

Jooste PL "Epileptic‐type convulsions and magnesium deficiency" Aviat Space Environ Med (1979)

[40]

10.1111/j.1440-1681.1987.tb00985.x

[41]

Ahsan SK "Hypomagnesemia and clinical implications in children and neonates" Indian J Med Sci (1998)

[42]

10.1681/asn.2004110989

[43]

10.1007/s13312-015-0668-0

[44]

10.1016/j.braindev.2014.06.006

[45]

Capron G (1853)

[46]

10.1017/s0317167100013457

[47]

Pandey M "Refractory status epilepticus—magnesium as rescue therapy" Anaesthes Intensive Care (2010)

[48]

10.1016/s0167-4889(97)00077-3

[49]

10.1016/s0091-3057(96)00555-2

[50]

10.1016/j.brainres.2010.03.076

Showing 50 of 67 references

Metrics

12

Citations

67

References

Details

Published: Oct 26, 2015
Vol/Issue: 56(3)
Pages: 260-265
License: View

Authors

K

Katie E. Osborn

Department of Psychiatry & Behavioral Neurosciences University of South Florida Morsani College of Medicine Tampa FL USA; Geisel School of Medicine at Dartmouth, Hanover NH USA

R

R. Douglas Shytle

Center for Excellence in Aging and Brain Repair, Department of Neurosurgery & Brain Repair University of South Florida Morsani College of Medicine Tampa FL USA

A

Alfred T. Frontera

Department of Neurology University of South Florida Morsani College of Medicine Tampa FL USA

J

Jason R. Soble

Psychology Service South Texas Veterans Health Care System San Antonio TX USA

M

Mike R. Schoenberg

Department of Psychiatry & Behavioral Neurosciences University of South Florida Morsani College of Medicine Tampa FL USA; Center for Excellence in Aging and Brain Repair, Department of Neurosurgery & Brain Repair University of South Florida Morsani College of Medicine Tampa FL USA; Department of Neurology University of South Florida Morsani College of Medicine Tampa FL USA

Cite This Article

Katie E. Osborn, R. Douglas Shytle, Alfred T. Frontera, et al. (2015). Addressing potential role of magnesium dyshomeostasis to improve treatment efficacy for epilepsy: A reexamination of the literature. The Journal of Clinical Pharmacology, 56(3), 260-265. https://doi.org/10.1002/jcph.626

Addressing potential role of magnesium dyshomeostasis to improve treatment efficacy for epilepsy: A reexamination of the literature

You May Also Like