Red blood cell alloantibodies in paediatric transfusion in sub‐Saharan Africa: A new cohort and literature review

Macoura Gadji; Guéda Cobar; Alioune Thiongane; Alioune Badara Senghor; Rose Seck; Blaise Félix Faye; Moussa Seck; Youssou Bamar Guéye; Diariétou Sy; Abibatou Sall; Awa Oumar Toure; Tandakha Ndiaye Diéye; Saliou Diop

doi:10.1002/jha2.645

journal article Open Access Feb 09, 2023

Red blood cell alloantibodies in paediatric transfusion in sub‐Saharan Africa: A new cohort and literature review

Macoura Gadji

Guéda Cobar Alioune Thiongane Alioune Badara Senghor Rose Seck Blaise Félix Faye Moussa Seck

Youssou Bamar Guéye Diariétou Sy Abibatou Sall Awa Oumar Toure Tandakha Ndiaye Diéye Saliou Diop

eJHaem Vol. 4 No. 2 pp. 315-323 · Wiley

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Abstract

AbstractBlood transfusion support predisposes transfused children to the risk of erythrocyte alloimmunization in Sub‐Saharan Africa. A cohort of 100 children receiving one to five blood transfusions were recruited for screening and identification of irregular antibodies using gel filtration technique. The mean age was 8 years and the sex‐ratio at 1.2. The retrieved pathologies were: major sickle cell anaemia (46%), severe malaria (20%), haemolytic anaemia (4%), severe acute malnutrition (6%), acute gastroenteritis (5%), chronic infectious syndrome (12%) and congenital heart disease (7%). The children presented with haemoglobin levels ≤6 g/dl, and 16% of them presented positive irregular antibodies directed against the Rhesus (30.76%) and Kell (69.24%) blood group systems. A literature review shows that irregular antibody screenings vary from 17% to 30% of transfused paediatric patients in Sub‐Saharan Africa. These alloantibodies are in particular directed against the Rhesus, Kell, Duffy, Kidd and MNS blood group and generally found in sickle cell disease and malaria. This study highlights the urgent need of extended red blood cell phenotyping including typing for C/c, E/e, K/k, and Fya/Fyb, and if possible Jka/Jkb, M/N, and S/s for children before transfusion in Sub‐Saharan Africa.

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Details

Published: Feb 09, 2023
Vol/Issue: 4(2)
Pages: 315-323
License: View

Authors

M

Macoura Gadji

Service of Haematology and Oncology‐Haematology (HBOH) Department of Biology and Applied Pharmaceutical Sciences Faculty of Medicine Pharmacy and Odonto‐Stomatology (FMPOS) University Cheikh Anta Diop of Dakar (UCAD) Dakar Senegal; National Centre of Blood Transfusion (CNTS) Dakar Senegal

G

Guéda Cobar

Service of Haematology and Oncology‐Haematology (HBOH) Department of Biology and Applied Pharmaceutical Sciences Faculty of Medicine Pharmacy and Odonto‐Stomatology (FMPOS) University Cheikh Anta Diop of Dakar (UCAD) Dakar Senegal; National Centre of Blood Transfusion (CNTS) Dakar Senegal

A

Alioune Thiongane

Service of Paediatrics Department of Medicine, Hospital Albert Royer of Fann Faculty of Medicine Pharmacy and Odonto‐Stomatology (FMPOS) University Cheikh Anta Diop of Dakar (UCAD) Dakar Senegal

A

Alioune Badara Senghor

National Centre of Blood Transfusion (CNTS) Dakar Senegal

R

Rose Seck

National Centre of Blood Transfusion (CNTS) Dakar Senegal

B

Blaise Félix Faye

National Centre of Blood Transfusion (CNTS) Dakar Senegal; Service of Haematology Department of Medicine, Faculty of Medicine Pharmacy and Odonto‐Stomatology (FMPOS) University Cheikh Anta Diop of Dakar (UCAD) Dakar Senegal

M

Moussa Seck

National Centre of Blood Transfusion (CNTS) Dakar Senegal; Service of Haematology Department of Medicine, Faculty of Medicine Pharmacy and Odonto‐Stomatology (FMPOS) University Cheikh Anta Diop of Dakar (UCAD) Dakar Senegal

Y

Youssou Bamar Guéye

National Centre of Blood Transfusion (CNTS) Dakar Senegal

D

Diariétou Sy

National Centre of Blood Transfusion (CNTS) Dakar Senegal

A

Abibatou Sall

Service of Haematology Department of Medicine, Faculty of Medicine Pharmacy and Odonto‐Stomatology (FMPOS) University Cheikh Anta Diop of Dakar (UCAD) Dakar Senegal

A

Awa Oumar Toure

Service of Haematology Department of Medicine, Faculty of Medicine Pharmacy and Odonto‐Stomatology (FMPOS) University Cheikh Anta Diop of Dakar (UCAD) Dakar Senegal; Service of Biology Hospital Aristide le Dantec Dakar Senegal

T

Tandakha Ndiaye Diéye

National Centre of Blood Transfusion (CNTS) Dakar Senegal; Service of Immunology Department of Biology and Applied Pharmaceutical Sciences Faculty of Medicine Pharmacy and Odonto‐Stomatology (FMPOS) University Cheikh Anta Diop of Dakar (UCAD) Dakar Senegal

S

Saliou Diop

National Centre of Blood Transfusion (CNTS) Dakar Senegal; Service of Haematology Department of Medicine, Faculty of Medicine Pharmacy and Odonto‐Stomatology (FMPOS) University Cheikh Anta Diop of Dakar (UCAD) Dakar Senegal

Cite This Article

Macoura Gadji, Guéda Cobar, Alioune Thiongane, et al. (2023). Red blood cell alloantibodies in paediatric transfusion in sub‐Saharan Africa: A new cohort and literature review. eJHaem, 4(2), 315-323. https://doi.org/10.1002/jha2.645

Red blood cell alloantibodies in paediatric transfusion in sub‐Saharan Africa: A new cohort and literature review

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