Synthesis and antitumor activities of novel bis‐quinazolin‐4(3H)‐ones

Nasrin Rahmannejadi; Issa Yavari; Soghra Khabnadideh

doi:10.1002/jhet.3749

journal article Jan 06, 2020

Synthesis and antitumor activities of novel bis‐quinazolin‐4(3H)‐ones

Nasrin Rahmannejadi Issa Yavari

Soghra Khabnadideh

Journal of Heterocyclic Chemistry Vol. 57 No. 3 pp. 978-982 · Wiley

View at Publisher Save 10.1002/jhet.3749

Abstract

AbstractWith the aim of obtaining new antitumor agents, a series of bis‐quinazolin‐4(3H)‐ones (3a‐3 f) were designed and synthesized. These products contain 4‐oxo‐1,2,3,4‐tetrahydro‐quinazoline and 3H‐quinazolin‐4‐one moieties linked together via a propyl chain. Cytotoxic activities of 3a‐3 f were evaluated against lung adenocarcinoma (A549), breast carcinoma (MCF‐7) and ovarian cancer (SKOV3) cell lines using MTT method. Cisplatin was used as a positive control. Among the tested compounds 3a, 3b, and 3e showed the best cytotoxic activities against all cancerous cell lines with IC50 values even less than cisplatin. Compounds 3d and 3f also showed desirable cytotoxic activities especially against A549 and MCF‐7.

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Metrics

21

Citations

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References

Details

Published: Jan 06, 2020
Vol/Issue: 57(3)
Pages: 978-982
License: View

Authors

N

Nasrin Rahmannejadi

Department of Chemistry, Science and Research Branch Islamic Azad University Tehran Iran

I

Issa Yavari

Department of Chemistry Tarbiat Modares University P.O. Box 14115‐175 Tehran Iran

S

Soghra Khabnadideh

Pharmaceutical Science Research Center Shiraz University of Medical Sciences Shiraz Iran

Funding

Shiraz University of Medical Sciences Award: 93‐01‐05‐7690

Cite This Article

Nasrin Rahmannejadi, Issa Yavari, Soghra Khabnadideh (2020). Synthesis and antitumor activities of novel bis‐quinazolin‐4(3H)‐ones. Journal of Heterocyclic Chemistry, 57(3), 978-982. https://doi.org/10.1002/jhet.3749

Synthesis and antitumor activities of novel bis‐quinazolin‐4(3H)‐ones

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