Enhanced analgesic effects of tramadol and common trace element coadministration in mice

Teodora Alexa; Aurelia Marza; Tudor Voloseniuc; Bogdan Tamba

doi:10.1002/jnr.23609

journal article Jun 16, 2015

Enhanced analgesic effects of tramadol and common trace element coadministration in mice

Teodora Alexa Aurelia Marza Tudor Voloseniuc Bogdan Tamba

Journal of Neuroscience Research Vol. 93 No. 10 pp. 1534-1541 · Wiley

View at Publisher Save 10.1002/jnr.23609

Abstract

Chronic pain is managed mostly by the daily administration of analgesics. Tramadol is one of the most commonly used drugs, marketed in combination with coanalgesics for enhanced effect. Trace elements are frequent ingredients in dietary supplements and may enhance tramadol's analgesic effect either through synergic mechanisms or through analgesic effects of their own. Swiss Weber male mice were divided into nine groups and were treated with a combination of the trace elements Mg, Mn, and Zn in three different doses and a fixed dose of tramadol. Two groups served as positive (tramadol alone) and negative (saline) controls. Nociceptive assessment by tail‐flick (TF) and hot‐plate (HP) tests was performed at baseline and at 15, 30, 45, and 60 min after intraperitoneal administration. Response latencies were recorded and compared with the aid of ANOVA testing. All three trace elements enhanced tramadol's analgesic effect, as assessed by TF and HP test latencies. Coadministration of these trace elements led to an increase of approximately 30% in the average pain inhibition compared with the tramadol‐alone group. The most effective doses were 0.6 mg/kg b.w. for Zn, 75 mg/kg b.w. for Mg, and 7.2 mg/kg b.w. for Mn. Associating trace elements such as Zn, Mg, and Mn with the standard administration of tramadol increases the drug's analgesic effect, most likely a consequence of their synergic action. These findings impact current analgesic treatment because the addition of these trace elements may reduce the tramadol dose required to obtain analgesia. © 2015 Wiley Periodicals, Inc.

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References

Details

Published: Jun 16, 2015
Vol/Issue: 93(10)
Pages: 1534-1541
License: View

Authors

T

Teodora Alexa

Centre for the Study and Therapy of Pain University of Medicine and Pharmacy “Gr. T. Popa,” Iaşi Romania; Regional Institute of Oncology Iaşi Romania

A

Aurelia Marza

Centre for the Study and Therapy of Pain University of Medicine and Pharmacy “Gr. T. Popa,” Iaşi Romania

T

Tudor Voloseniuc

Centre for the Study and Therapy of Pain University of Medicine and Pharmacy “Gr. T. Popa,” Iaşi Romania

B

Bogdan Tamba

Centre for the Study and Therapy of Pain University of Medicine and Pharmacy “Gr. T. Popa,” Iaşi Romania; A&B Pharm Corporation Roman Romania

Funding

POSDRU Award: 159/1.5/S/136893

DocMed.net_2.0

Cite This Article

Teodora Alexa, Aurelia Marza, Tudor Voloseniuc, et al. (2015). Enhanced analgesic effects of tramadol and common trace element coadministration in mice. Journal of Neuroscience Research, 93(10), 1534-1541. https://doi.org/10.1002/jnr.23609

Enhanced analgesic effects of tramadol and common trace element coadministration in mice

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