The role of the macrophage in tendinopathy and tendon healing

Joo Y. Sunwoo; Claire D. Eliasberg; Camila B. Carballo; Scott A. Rodeo

doi:10.1002/jor.24667

journal article Mar 30, 2020

The role of the macrophage in tendinopathy and tendon healing

Joo Y. Sunwoo Claire D. Eliasberg

Camila B. Carballo Scott A. Rodeo

Journal of Orthopaedic Research Vol. 38 No. 8 pp. 1666-1675 · Wiley

View at Publisher Save 10.1002/jor.24667

Abstract

AbstractThe role of the macrophage is an area of emerging interest in tendinopathy and tendon healing. The macrophage has been found to play a key role in regulating the healing process of the healing tendon. The specific function of the macrophage depends on its functional phenotype. While the M1 macrophage phenotype exhibits a phagocytic and proinflammatory function, the M2 macrophage phenotype is associated with the resolution of inflammation and tissue deposition. Several studies have been conducted on animal models looking at enhancing or suppressing macrophage function, targeting specific phenotypes. These studies include the use of exogenous biological and pharmacological substances and more recently the use of transgenic and genetically modified animals. The outcomes of these studies have been promising. In particular, enhancement of M2 macrophage activity in the healing tendon of animal models have shown decreased scar formation, accelerated healing, decreased inflammation and even enhanced biomechanical strength. Currently our understanding of the role of the macrophage in tendinopathy and tendon healing is limited. Furthermore, the roles of therapies targeting macrophages to enhance tendon healing is unclear. Clinical Significance: An increased understanding of the significance of the macrophage and its functional phenotypes in the healing tendon may be the key to enhancing tendon healing. This review will present the current literature on the function of macrophages in tendinopathy and tendon healing and the potential of therapies targeting macrophages to enhance tendon healing.

Topics

No keywords indexed for this article. Browse by subject →

References

53

[1]

Sharma P "Tendon injury and tendinopathy: healing and repair" J Bone Joint Surg Am (2005)

[2]

10.1114/1.1616931

[3]

10.1017/s1462399411001943

[4]

10.1172/jci59643

[5]

10.1038/nri2448

[6]

Macrophage polarization: tumor-associated macrophages as a paradigm for polarized M2 mononuclear phagocytes

A MANTOVANI, S SOZZANI, M LOCATI et al.

Trends in Immunology 10.1016/s1471-4906(02)02302-5

[7]

10.1002/jor.22504

[8]

10.1016/s0363-5023(80)80075-x

[9]

10.1002/jor.22624

[10]

10.1302/0301-620x.88b4.16845

[11]

10.1016/s0736-0266(01)00031-6

[12]

10.1111/j.1365-2249.1993.tb06505.x

[13]

PERSPECTIVE ARTICLE: Growth factors and cytokines in wound healing

Stephan Barrientos, Olivera Stojadinovic, Michael S. Golinko et al.

Wound Repair and Regeneration 10.1111/j.1524-475x.2008.00410.x

[14]

10.1172/jci1112

[15]

10.1002/jbm.a.35156

[16]

10.2741/2692

[17]

10.1242/dmm.041384

[18]

10.1016/j.jacc.2018.08.2148

[19]

10.3109/03008207.2010.511355

[20]

10.1186/s13287-015-0059-4

[21]

10.1371/journal.pone.0181127

[22]

Hypertrophic Scar Fibroblasts Have Increased Connective Tissue Growth Factor Expression after Transforming Growth Factor-?? Stimulation

Amy S. Colwell, Toan-Thang Phan, Wuyi Kong et al.

Plastic & Reconstructive Surgery 10.1097/01.prs.0000182343.99694.28

[23]

10.1136/bmjsem-2017-000332

[24]

10.1177/03946320110241s209

[25]

10.1177/0363546510372613

[26]

Chronic inflammation is a feature of Achilles tendinopathy and rupture

Stephanie Georgina Dakin, Julia Newton, Fernando O Martinez et al.

British Journal of Sports Medicine 10.1136/bjsports-2017-098161

[27]

10.1177/0363546514542329

[28]

10.1136/bjsm.2007.040212

[29]

10.1038/s41598-018-37684-3

[30]

10.1016/j.orthres.2005.01.014.1100230627

[31]

10.1016/j.arthro.2017.10.045

[32]

10.1161/atvbaha.111.222745

[33]

10.1111/cei.12857

[34]

CarballoCN WadaY Sekvaggio E S et al.2019.Characterization of macrophage function and inflammatory response through gene expression profiling in a murine rotator cuff repair model. Poster session presented at the annual meeting of the Orthopaedic Research Society Austin TX.

[35]

10.1080/03008200590935501

[36]

10.1152/ajpregu.00411.2005

[37]

10.1097/01.lab.0000078688.07696.ac

[38]

10.1177/0363546504263403

[39]

Extracellular Vesicle-Educated Macrophages Promote Early Achilles Tendon Healing

Connie S. Chamberlain, Anna E. B. Clements, John A. Kink et al.

Stem Cells 10.1002/stem.2988

[40]

10.1186/s13287-016-0406-0

[41]

10.1007/s11999-017-5369-7

[42]

Barboni B "Therapeutic potential of hAECs for early Achilles tendon defect repair through regeneration" J Tissue Eng Regener Med (2017)

[43]

10.1016/j.jbiomech.2004.11.009

[44]

10.1007/s11515-012-1192-4

[45]

10.1016/s0960-9822(03)00396-8

[46]

10.1038/srep09023

[47]

10.1172/jci11530

[48]

10.1111/wrr.12023

[49]

10.1016/j.ajpath.2014.08.017

[50]

10.2353/ajpath.2009.081002

Showing 50 of 53 references

Cited By

153

Bee sting-shaped microneedles for accelerating Achilles tendinopathy healing via enhanced regulating macrophage polarization

Muwei Hao, Kai Xiang · 2026

Journal of Nanobiotechnology

Injectable Piezoelectric Hydrogel Promotes Tendon–Bone Healing via Reshaping the Electrophysiological Microenvironment and M2 Macrophage Polarization

Xiaofei Li, Yubao Liu · 2025

ACS Applied Materials & Interfa...

Inhibition of peritendinous adhesion through targeting JAK2-STAT3 signaling pathway: The therapeutic potential of AG490

Xue Fang, Wang Zhang · 2024

International Immunopharmacology

Peritendinous adhesion: Therapeutic targets and progress of drug therapy

Shuo Wang, Pan Sha · 2024

Computational and Structural Biotec...

Macrophages regulated by cyclooxygenases promote tendon healing via Pla1a/Etv1 axis

Jin Jing, Yang Qian Qian · 2023

Chemical Engineering Journal

Pristimerin suppresses AIM2 inflammasome by modulating AIM2-PYCARD/ASC stability via selective autophagy to alleviate tendinopathy

Huaji Jiang, Yingchao Xie · 2023

Autophagy

Tendon healing: a concise review on cellular and molecular mechanisms with a particular focus on the Achilles tendon

Gundula G. Schulze-Tanzil, Manuel Delgado Cáceres · 2022

Bone & Joint Research

Regulating Macrophages through Immunomodulatory Biomaterials Is a Promising Strategy for Promoting Tendon-Bone Healing

Haihan Gao, Liren Wang · 2022

Journal of Functional Biomaterials

Human Organ-on-a-Chip Microphysiological Systems to Model Musculoskeletal Pathologies and Accelerate Therapeutic Discovery

Raquel E. Ajalik, Rahul G. Alenchery · 2022

Frontiers in Bioengineering and Bio...

Tendinopathy

Neal L. Millar, Karin G. Silbernagel · 2021

Nature Reviews Disease Primers

Metrics

153

Citations

53

References

Details

Published: Mar 30, 2020
Vol/Issue: 38(8)
Pages: 1666-1675
License: View

Authors

J

Joo Y. Sunwoo

Orthopaedic Soft Tissue Research Program Hospital for Special Surgery New York New York

C

Claire D. Eliasberg

Orthopaedic Soft Tissue Research Program Hospital for Special Surgery New York New York

C

Camila B. Carballo

Orthopaedic Soft Tissue Research Program Hospital for Special Surgery New York New York

S

Scott A. Rodeo

Orthopaedic Soft Tissue Research Program Hospital for Special Surgery New York New York

Cite This Article

Joo Y. Sunwoo, Claire D. Eliasberg, Camila B. Carballo, et al. (2020). The role of the macrophage in tendinopathy and tendon healing. Journal of Orthopaedic Research, 38(8), 1666-1675. https://doi.org/10.1002/jor.24667

The role of the macrophage in tendinopathy and tendon healing

You May Also Like