Comparing Palliative Approaches for GOO in Locally Advanced Pancreatic Cancer: A Systematic Review and Meta‐Analysis

Asad Gul Rao; Muhammad Ahmad Nadeem; Abdul Rafeh Awan; Chase J. Wehrle; Abby Gross; Antonio Giuseppucci; Beren Berber; Syed Mohiuddin; Tyler Stevens; Hassan Siddiki; Kathryn A. Stackhouse; Samer Naffouje; Daniel Joyce; Toms Augustin; Robert Simon; R. Matthew Walsh; Rob Naples

doi:10.1002/jso.70131

journal article Nov 16, 2025

Comparing Palliative Approaches for GOO in Locally Advanced Pancreatic Cancer: A Systematic Review and Meta‐Analysis

Asad Gul Rao

Muhammad Ahmad Nadeem Abdul Rafeh Awan

Chase J. Wehrle Abby Gross

Antonio Giuseppucci Beren Berber Syed Mohiuddin Tyler Stevens Hassan Siddiki Kathryn A. Stackhouse Samer Naffouje Daniel Joyce

Toms Augustin Robert Simon R. Matthew Walsh Rob Naples

Journal of Surgical Oncology Vol. 133 No. 1 pp. 81-91 · Wiley

View at Publisher Save 10.1002/jso.70131

Abstract

ABSTRACT
Gastric outlet obstruction (GOO) in locally advanced pancreatic cancer (LAPC) can be managed with endoscopic duodenal stenting (EDS), gastrojejunostomy (GJ), or EUS‐guided gastroenterostomy (EUS‐GE). In our meta‐analysis of LAPC patients, EDS enabled quicker recovery and chemotherapy but had higher re‐intervention rates, while GJ offered greater durability. Our systematic review showed EUS‐GE had high success and low re‐intervention in malignant GOO, though LAPC‐specific data were lacking. Further comparative studies are needed to guide individualized treatment.

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Details

Published: Nov 16, 2025
Vol/Issue: 133(1)
Pages: 81-91
License: View

Authors

A

Asad Gul Rao

Dow University of Health Sciences Karachi Pakistan

M

Muhammad Ahmad Nadeem