An updated review of the epidemiological factors associated with recurrent respiratory papillomatosis

Alexandra Welschmeyer; Gerald S. Berke

doi:10.1002/lio2.521

journal article Open Access Jan 28, 2021

An updated review of the epidemiological factors associated with recurrent respiratory papillomatosis

Alexandra Welschmeyer

Gerald S. Berke

Laryngoscope Investigative Otolaryngology Vol. 6 No. 2 pp. 226-233 · Wiley

View at Publisher Save 10.1002/lio2.521

Abstract

AbstractObjectivesTo identify studies evaluating the epidemiology of recurrent respiratory papillomatosis (RRP), including patient demographics, human papillomavirus (HPV) immunology, clinical course, surgical and medical treatments, and psychosocial factors.MethodsA systematic literature search through PubMed was performed to identify studies evaluating the epidemiological factors associated with RRP. All studies were screened through a priori selection criteria using the titles and abstracts.ResultsA total of 208 studies were identified, of which 54 met eligibility criteria and were included in the review.ConclusionsRRP is a rare disease most commonly caused by HPV 6 and 11. It is characterized by recurring benign papillomatous lesions in the respiratory tract, particularly the larynx. Existing evidence about disease risk factors is limited but includes both maternal HPV infection and patient smoking and sexual behaviors. Disease management involves a combination of routine surgical and medical treatment. Surgical techniques include CO2‐laser, sharp dissection, coblation, microdebridement, and photoangiolytic laser. Medical treatments which have been found to facilitate disease control off‐label include interferon‐alpha (IFN‐α), indole‐3‐carbinol, acyclovir, bevacizumab, retinoids, and the Gardasil and mumps vaccines. Many patients suffer from additional psychosocial challenges related to their diagnosis. Current disease knowledge remains limited, and more robust controlled trials about risk factors, medical therapies, and surgical options are needed.Level of Evidence5.

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References

Details

Published: Jan 28, 2021
Vol/Issue: 6(2)
Pages: 226-233
License: View

Authors

A

Alexandra Welschmeyer

Georgetown University School of Medicine Washington District of Columbia USA

G

Gerald S. Berke

Department of Head and Neck Surgery Ronald Reagan UCLA Medical Center Los Angeles California USA

Cite This Article

Alexandra Welschmeyer, Gerald S. Berke (2021). An updated review of the epidemiological factors associated with recurrent respiratory papillomatosis. Laryngoscope Investigative Otolaryngology, 6(2), 226-233. https://doi.org/10.1002/lio2.521

An updated review of the epidemiological factors associated with recurrent respiratory papillomatosis

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