Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF‐A induced angiogenesis

Kai Lü; Madhavi Bhat; Sara Peters; Rita Mitra; Tatiana Oberyszyn; Sujit Basu

doi:10.1002/mc.23281

journal article Jan 22, 2021

Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF‐A induced angiogenesis

Kai Lü

Madhavi Bhat Sara Peters Rita Mitra Tatiana Oberyszyn Sujit Basu

Molecular Carcinogenesis Vol. 60 No. 3 pp. 172-178 · Wiley

View at Publisher Save 10.1002/mc.23281

Abstract

AbstractAlthough beta 2 adrenergic receptors (β2ADR) are present in the keratinocytes, their role in cutaneous squamous cell tumorigenesis needs to be ascertained. For the first time, we report here that selective β2ADR antagonists by inhibiting β2ADR actions significantly retarded the progression of ultraviolet B (UVB) induced premalignant cutaneous squamous cell lesions. These antagonists acted by inhibiting vascular endothelial growth factor‐A (VEGF) mediated angiogenesis to prevent UVB radiation‐induced squamous cell carcinoma of the skin.

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Citations

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References

Details

Published: Jan 22, 2021
Vol/Issue: 60(3)
Pages: 172-178
License: View

Authors

K

Kai Lü

Department of Pathology Ohio State University Columbus USA

M

Madhavi Bhat

Department of Pathology Ohio State University Columbus USA

S

Sara Peters

Department of Pathology Ohio State University Columbus USA

R

Rita Mitra

Department of Pathology KPC Medical College Kolkata India

T

Tatiana Oberyszyn

Department of Pathology Ohio State University Columbus USA; Comprehensive Cancer Center Ohio State University Columbus USA

S

Sujit Basu

Department of Pathology Ohio State University Columbus USA; Comprehensive Cancer Center Ohio State University Columbus USA; Division of Medical Oncology, Department of Internal Medicine Ohio State University Columbus USA

Funding

National Heart, Lung, and Blood Institute Award: R01HL131405

U.S. Department of Defense Award: W81XWH‐12‐1‐0443

Cite This Article

Kai Lü, Madhavi Bhat, Sara Peters, et al. (2021). Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF‐A induced angiogenesis. Molecular Carcinogenesis, 60(3), 172-178. https://doi.org/10.1002/mc.23281

Suppression of beta 2 adrenergic receptor actions prevent UVB mediated cutaneous squamous cell tumorigenesis through inhibition of VEGF‐A induced angiogenesis

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