Epigenetic regulation in lung cancer

Shahin Ramazi; Maedeh Dadzadi; Zahra Sahafnejad; Abdollah Allahverdi

doi:10.1002/mco2.401

journal article Open Access Oct 26, 2023

Epigenetic regulation in lung cancer

Shahin Ramazi Maedeh Dadzadi Zahra Sahafnejad Abdollah Allahverdi

MedComm Vol. 4 No. 6 · Wiley

View at Publisher Save 10.1002/mco2.401

Abstract

AbstractLung cancer is indeed a major cause of cancer‐related deaths worldwide. The development of tumors involves a complex interplay of genetic, epigenetic, and environmental factors. Epigenetic mechanisms, including DNA methylation (DNAm), histone modifications, and microRNA expression, play a crucial role in this process. Changes in DNAm patterns can lead to the silencing of important genes involved in cellular functions, contributing to the development and progression of lung cancer. MicroRNAs and exosomes have also emerged as reliable biomarkers for lung cancer. They can provide valuable information about early diagnosis and treatment assessment. In particular, abnormal hypermethylation of gene promoters and its effects on tumorigenesis, as well as its roles in the Wnt signaling pathway, have been extensively studied. Epigenetic drugs have shown promise in the treatment of lung cancer. These drugs target the aberrant epigenetic modifications that are involved in the development and progression of the disease. Several factors have been identified as drug targets in non‐small cell lung cancer. Recently, combination therapy has been discussed as a successful strategy for overcoming drug resistance. Overall, understanding the role of epigenetic mechanisms and their targeting through drugs is an important area of research in lung cancer treatment.

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Details

Published: Oct 26, 2023
Vol/Issue: 4(6)
License: View

Authors

S

Shahin Ramazi

Department of Biophysics Faculty of Biological Sciences Tarbiat Modares University Tehran Iran

M

Maedeh Dadzadi

Department of Biotechnology Faculty of Advanced Science and Technology Tehran Medical Sciences Islamic Azad University Tehran Iran

Z

Zahra Sahafnejad

Department of Biophysics Faculty of Biological Sciences Tarbiat Modares University Tehran Iran

A

Abdollah Allahverdi

Department of Biophysics Faculty of Biological Sciences Tarbiat Modares University Tehran Iran

Funding

Iran National Science Foundation Award: 96006759

Cite This Article

Shahin Ramazi, Maedeh Dadzadi, Zahra Sahafnejad, et al. (2023). Epigenetic regulation in lung cancer. MedComm, 4(6). https://doi.org/10.1002/mco2.401

Epigenetic regulation in lung cancer

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