Nigral burden of α‐synuclein correlates with striatal dopamine deficit

Gabor G. Kovacs; Ivan J. Milenkovic; Matthias Preusser; Herbert Budka

doi:10.1002/mds.22207

journal article Jul 22, 2008

Nigral burden of α‐synuclein correlates with striatal dopamine deficit

Gabor G. Kovacs

Ivan J. Milenkovic Matthias Preusser

Herbert Budka

Movement Disorders Vol. 23 No. 11 pp. 1608-1612 · Wiley

View at Publisher Save 10.1002/mds.22207

Abstract

AbstractAggregated α‐synuclein is the hallmark of Parkinson's disease (PD), diffuse Lewy body disease (DLBD), and multiple system atrophy (MSA). Physiologically, α‐synuclein ensures normal functions of dopamine transporter (DAT) and tyrosine hydoxylase. In α‐synucleinopathies, it accumulates in neuronal cytoplasm and neurites through several stages. It is unclear whether the accumulation of pathological α‐synuclein in the substantia nigra in PD correlates with the dopaminergic deficit in the striatal target. We evaluated the impact of the nigral burden of pathological α‐synuclein immunoreactivity in 27 α‐synucleinopathy brains by morphometric immunohistochemistry. DAT immunoreactivity in the striatum inversely correlates with the total α‐synuclein burden in the substantia nigra but not with cytoplasmic inclusion counts only. This result has implications for imaging, clinicopathological correlative studies, and staging of the disease process. © 2008 Movement Disorder Society

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Metrics

50

Citations

15

References

Details

Published: Jul 22, 2008
Vol/Issue: 23(11)
Pages: 1608-1612
License: View

Authors

Cite This Article

Gabor G. Kovacs, Ivan J. Milenkovic, Matthias Preusser, et al. (2008). Nigral burden of α‐synuclein correlates with striatal dopamine deficit. Movement Disorders, 23(11), 1608-1612. https://doi.org/10.1002/mds.22207

Nigral burden of α‐synuclein correlates with striatal dopamine deficit

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