NMR quantification using an artificial signal

Roger D. Farrant; John C. Hollerton; Sean M. Lynn; Stefano Provera; Philip J. Sidebottom; Richard J. Upton

doi:10.1002/mrc.2647

journal article Aug 27, 2010

NMR quantification using an artificial signal

Roger D. Farrant John C. Hollerton Sean M. Lynn Stefano Provera Philip J. Sidebottom Richard J. Upton

Magnetic Resonance in Chemistry Vol. 48 No. 10 pp. 753-762 · Wiley

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Abstract

AbstractWe have developed QUANTAS (QUANTification by Artificial Signal), which is a software‐based protocol for concentration measurement by NMR. QUANTAS is an absolute intensity external standard method for quantification by NMR that compensates for various experimental parameters. It is applicable to all nuclei and modern spectrometers. QUANTAS is demonstrated here for 1H and 19F NMR, enabling heteronuclear integrals to be compared. It can be applied using fixed probe tuning, matching and pulse length, for samples with the same effective loading on the probe coil as the appropriate reference spectrum. Otherwise, an optimised tuning and matching approach is adopted for every sample together with explicit PULCON (PUlse Length‐based CONcentration measurements) absolute intensity corrections. Copyright © 2010 John Wiley & Sons, Ltd.

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Details

Published: Aug 27, 2010
Vol/Issue: 48(10)
Pages: 753-762
License: View

Authors

Cite This Article

Roger D. Farrant, John C. Hollerton, Sean M. Lynn, et al. (2010). NMR quantification using an artificial signal. Magnetic Resonance in Chemistry, 48(10), 753-762. https://doi.org/10.1002/mrc.2647

NMR quantification using an artificial signal

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