Damages and stress responses in sperm cells and other germplasms during dehydration and storage at nonfreezing temperatures for fertility preservation

Pierre Comizzoli; Olga Amelkina; Pei‐Chih Lee

doi:10.1002/mrd.23651

journal article Nov 12, 2022

Damages and stress responses in sperm cells and other germplasms during dehydration and storage at nonfreezing temperatures for fertility preservation

Pierre Comizzoli

Olga Amelkina Pei‐Chih Lee

Molecular Reproduction and Development Vol. 89 No. 12 pp. 565-578 · Wiley

View at Publisher Save 10.1002/mrd.23651

Abstract

AbstractLong‐term preservation of sperm, oocytes, and gonadal tissues at ambient temperatures has the potential to lower the costs and simplify biobanking in human reproductive medicine, as well as for the management of animal populations. Over the past decades, different dehydration protocols and long‐term storage solutions at nonfreezing temperatures have been explored, mainly for mammalian sperm cells. Oocytes and gonadal tissues are more challenging to dehydrate so little to no progress have been made. Currently, the detrimental effects of the drying process itself are better characterized than the impact of long‐term storage at nonfreezing temperatures. While structural and functional properties of germ cells can be preserved after dehydration, a long list of damages and stresses in nuclei, organelles, and cytoplasmic membranes have been reported and sometimes mitigated. Characterizing those damages and better understanding the response of germ cells and tissues to the stress of dehydration is fundamental. It will contribute to the development of optimal protocols while proving the safety of alternative storage options for fertility preservation. The objective of this review is to (1) document the types of damages and stress responses, as well as their mitigation in cells dried with different techniques, and (2) propose new research directions.

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Metrics

13

Citations

127

References

Details

Published: Nov 12, 2022
Vol/Issue: 89(12)
Pages: 565-578
License: View

Authors

P

Pierre Comizzoli

Smithsonian's National Zoo and Conservation Biology Institute Veterinary Hospital Washington District of Columbia USA

O

Olga Amelkina

Smithsonian's National Zoo and Conservation Biology Institute Veterinary Hospital Washington District of Columbia USA

P

Pei‐Chih Lee

Smithsonian's National Zoo and Conservation Biology Institute Veterinary Hospital Washington District of Columbia USA

Funding

National Institutes of Health

Cite This Article

Pierre Comizzoli, Olga Amelkina, Pei‐Chih Lee (2022). Damages and stress responses in sperm cells and other germplasms during dehydration and storage at nonfreezing temperatures for fertility preservation. Molecular Reproduction and Development, 89(12), 565-578. https://doi.org/10.1002/mrd.23651

Damages and stress responses in sperm cells and other germplasms during dehydration and storage at nonfreezing temperatures for fertility preservation

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