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journal article Jun 27, 2002

Mapping myocardial perfusion with an intravascular MR contrast agent: Robustness of deconvolution methods at various blood flows

Bruno Neyran Marc F. Janier Cendrine Casali Didier Revel Emmanuelle P. Canet Soulas
Magnetic Resonance in Medicine Vol. 48 No. 1 pp. 166-179 · Wiley
View at Publisher Save 10.1002/mrm.10201
Abstract
AbstractEvaluation of quantitative parameters such as regional myocardial blood flow (rMBF), blood volume (rMBV), and mean transit time (rMTT) by MRI is gaining acceptance for clinical applications, but still lacks robust postprocessing methods for map generation. Moreover, robustness should be preserved over the full range of myocardial flows and volumes. Using experimental data from an isolated pig heart preparation, synthetic MR kinetics were generated and four deconvolution approaches were evaluated. These methods were then applied to the first‐pass T1 images of the isolated pig heart using an intravascular contrast agent and rMBF, rMBV and rMTT maps were generated. In both synthetic and experimental data, the fit between calculated and original data reached equally good results with the four techniques. rMBV was the only parameter estimated correctly in numerical experiments. Moreover, using the algebraic method ARMA, abnormal regions were well delineated on rMBV maps. At high flows, rMBF was underestimated at the experimental noise level. Finally, rMTT maps appeared noisy and highly unreliable, especially at high flows. In conclusion, over the myocardial flow range, i.e., 0–400 ml/min/100g, rMBF identification was biased in presence of noise, whereas rMBV was correctly identified. Thus, rMBV mapping could be a fast and robust way to detect abnormal myocardial regions. Magn Reson Med 48:166–179, 2002. © 2002 Wiley‐Liss, Inc.
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Cited By
31
Imaging of myocardial perfusion with magnetic resonance

Jörg Barkhausen, Peter Hunold · 2004

Journal of Magnetic Resonance Imagi...
Metrics
31
Citations
39
References
Details
Published
Jun 27, 2002
Vol/Issue
48(1)
Pages
166-179
License
View
Authors
B
Bruno Neyran
M
Marc F. Janier
C
Cendrine Casali
D
Didier Revel
E
Emmanuelle P. Canet Soulas
Cite This Article
Bruno Neyran, Marc F. Janier, Cendrine Casali, et al. (2002). Mapping myocardial perfusion with an intravascular MR contrast agent: Robustness of deconvolution methods at various blood flows. Magnetic Resonance in Medicine, 48(1), 166-179. https://doi.org/10.1002/mrm.10201
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