Metabolite and macromolecule T1 and T2 relaxation times in the rat brain in vivo at 17.2T

Alfredo L. Lopez‐Kolkovsky; Sébastien Mériaux; Fawzi Boumezbeur

doi:10.1002/mrm.25602

journal article Mar 29, 2015

Metabolite and macromolecule T1 and T2 relaxation times in the rat brain in vivo at 17.2T

Alfredo L. Lopez‐Kolkovsky Sébastien Mériaux Fawzi Boumezbeur

Magnetic Resonance in Medicine Vol. 75 No. 2 pp. 503-514 · Wiley

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Abstract

PurposeTo measure the T1 and T2 relaxation times of water, metabolites, and macromolecules in the rat brain in vivo at 17.2T and achieve absolute quantification of the neurochemical profile. Relaxation times were compared with values from the literature found at lower magnetic fields.Methods1H NMR spectra were measured using a LASER localization sequence. T1‐ and T2‐weighted spectra were analyzed using LCModel with an original parameterization of the macromolecule baseline.ResultsThe T1 relaxation times of 20 metabolites and the T2 relaxation times of 16 singlets and J‐coupled metabolites were measured. The mean T1 and T2 relaxation times for metabolites were 1721 ± 237 ms and 148 ± 53 ms, respectively. In addition, we measured the T1 and T2 relaxation times of 4 macromolecule resonance groups, their mean T1 and T2 relaxation times being 690 ± 100 ms and 37 ± 15 ms, respectively. Absolute quantification of 21 metabolites and 4 groups of macromolecule resonances was achieved with Cramer‐Rao Lower Bounds below 5% for Cr, Gln, Glu, GPC, Ins, NAA, PCr, and Tau and below 25% for the remaining resonances.ConclusionComparison of our relaxation times to previously published values suggests a small increase of T1 values and a clear decrease of T2 values between 11.7 and 17.2T. Magn Reson Med 75:503–514, 2016. © 2015 Wiley Periodicals, Inc.

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References

53

[1]

10.1016/j.neurobiolaging.2004.07.001

[2]

10.1002/mrm.1910300405

[3]

10.1203/00006450-199112000-00017

[4]

10.1002/mrm.10367

[5]

10.1002/(sici)1099-1492(199701)10:1<2::aid-nbm442>3.0.co;2-n

[6]

10.1002/mrm.22148

[7]

10.1002/mrm.10490

[8]

10.1371/journal.pone.0077572

[9]

10.1118/1.595535

[10]

10.1002/mrm.1910320304

[11]

10.1007/s002340000473

[12]

10.1002/jmri.1880070626

[13]

10.1002/jmri.1880020303

[14]

10.1093/brain/117.1.49

[15]

10.3233/jad-2012-120100

[16]

10.1002/mrm.10332

[17]

10.1007/s10334-008-0104-8

[18]

10.1002/nbm.1767

[19]

Li Y "T1 and T2 Metabolite relaxation times in normal brain at 3T and 7T" J Mol Imaging Dyn (2012)

[20]

High magnetic field water and metabolite proton T1 and T2 relaxation in rat brain in vivo

Robin A. de Graaf, Peter B. Brown, Scott McIntyre et al.

Magnetic Resonance in Medicine 10.1002/mrm.20946

[21]

10.1002/mrm.22022

[22]

10.1002/nbm.1205

[23]

10.1007/s10334-013-0378-3

[24]

10.1016/0022-2364(84)90181-1

[25]

10.1002/(sici)1522-2594(199907)42:1<206::aid-mrm28>3.0.co;2-q

[26]

10.1002/cmmi.1489

[27]

10.1002/mrm.1910030602

[28]

10.1006/jmre.2001.2340

[29]

Automatic, localized in Vivo adjustment of all first‐and second‐order shim coils

Rolf Gruetter

Magnetic Resonance in Medicine 10.1002/mrm.1910290613

[30]

10.1006/jmrb.1993.1056

[31]

WET, a T1- and B1-Insensitive Water-Suppression Method for in Vivo Localized 1H NMR Spectroscopy

R.J. Ogg, R.B. Kingsley, J.S. Taylor

Journal of Magnetic Resonance, Series B 10.1006/jmrb.1994.1048

[32]

10.1016/0022-2364(92)90241-x

[33]

10.1002/mrm.1910300604

[34]

10.1002/cmr.1820060102

[35]

10.1002/1099-1492(200005)13:3<129::aid-nbm619>3.0.co;2-v

[36]

NearJ LeungI ClaridgeT CowenP JezzardP. Chemical shifts and coupling constants of the GABA spin system. In Proceedings of the 20th Scientific Meeting and Exhibition of the ISMRM in Melbourne Australia 2012. Abstract 4386.

[37]

10.1006/jmrb.1993.1055

[38]

Lentner C (1981)

[39]

Paxino G (1998)

[40]

10.1016/0730-725x(93)90418-d

[41]

10.1002/9780470512968

[42]

10.1002/mrm.22609

[43]

10.1002/mrm.1269

[44]

10.1103/physrev.73.679

[45]

10.1002/(sici)1522-2594(199906)41:6<1136::aid-mrm9>3.0.co;2-g

[46]

10.1002/nbm.3121

[47]

10.1002/chem.201300955

[48]

10.1002/mrm.10135

[49]

10.1002/mrm.25088

[50]

10.1002/mrm.22079

Showing 50 of 53 references

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Details

Published: Mar 29, 2015
Vol/Issue: 75(2)
Pages: 503-514
License: View

Authors

A

Alfredo L. Lopez‐Kolkovsky

NeuroSpin, I2BM, Commissariat à l'Energie Atomique Gif‐sur‐Yvette France

S

Sébastien Mériaux

NeuroSpin, I2BM, Commissariat à l'Energie Atomique Gif‐sur‐Yvette France

F

Fawzi Boumezbeur

NeuroSpin, I2BM, Commissariat à l'Energie Atomique Gif‐sur‐Yvette France

Cite This Article

Alfredo L. Lopez‐Kolkovsky, Sébastien Mériaux, Fawzi Boumezbeur (2015). Metabolite and macromolecule T1 and T2 relaxation times in the rat brain in vivo at 17.2T. Magnetic Resonance in Medicine, 75(2), 503-514. https://doi.org/10.1002/mrm.25602

Metabolite and macromolecule T1 and T2 relaxation times in the rat brain in vivo at 17.2T

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