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journal article Oct 24, 2017

Human umbilical cord blood relaxation times and susceptibility at 3 T

Sharon Portnoy Natasha Milligan Mike Seed John G. Sled ORCID Christopher K. Macgowan
Magnetic Resonance in Medicine Vol. 79 No. 6 pp. 3194-3206 · Wiley
View at Publisher Save 10.1002/mrm.26978
Abstract
PurposeTo characterize the magnetic susceptibility and relaxation times (T1 and T2) of fetal blood at 3 T as a function of the hematocrit (Hct) and oxygen saturation (sO2).MethodsSusceptibility and relaxometry measurements were performed on cord blood specimens (N = 90, derived from six caesarean deliveries) with a range of hematocrits and oxygen saturations (0.09 < Hct < 0.82, 7 < sO2 < 100%). To obtain simple, analytic relationships between MRI properties and blood properties, data were fit to established two‐compartment (plasma and erythrocytes) models.ResultsTwo‐compartment models effectively described the cord blood data. The root‐mean‐squared deviation between the model and the data was 6.3, 10.3, and 1.3% for fits to T1, T2, and susceptibility measurements. Relaxometry data and estimated T1 and T2 model parameters were generally consistent with those reported in cord blood at 1.5 T and comparable to published values for adult blood. Notably, the measured value of Δχdeo, the susceptibility difference between fully oxygenated (sO2 = 100%) and deoxygenated (sO2 = 0) cord blood was approximately 20% lower than the established adult blood value (Δχdeo,cord = 2.64 ppm, Δχdeo,adult = 3.4 ppm).ConclusionsThe described models and associated parameter values can be used to inform acquisition parameters, and interpret fetal/neonatal blood susceptibility measurements and relaxometry data acquired at 3 T with respect to hematocrit and sO2. Magn Reson Med 79:3194–3206, 2018. © 2017 International Society for Magnetic Resonance in Medicine.
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References
48
[7]
Polin R (2011)
[10]
Relaxation properties of human umbilical cord blood at 1.5 Tesla

Sharon Portnoy, Mark Osmond, Meng Yuan Zhu et al.

Magnetic Resonance in Medicine 10.1002/mrm.26231
[20]
Feynman R (2013)
[26]
Fullerton G (1983)
[36]
Vetterling WT (1992)
[39]
Neelavalli J (2014)
[42]
Rudolph A (2011)
Cited By
32
An MRI approach to assess placental function in healthy humans and sheep

Brahmdeep S. Saini, Jack R. T. Darby · 2021

The Journal of Physiology
The haemodynamics of the human placenta in utero

Neele S. Dellschaft, George Jack Hutchinson · 2020

PLOS Biology
Metrics
32
Citations
48
References
Details
Published
Oct 24, 2017
Vol/Issue
79(6)
Pages
3194-3206
License
View
Authors
S
Sharon Portnoy

Department of Medical Biophysics University of Toronto Toronto Ontario Canada; Mouse Imaging Centre Hospital for Sick Children Toronto Ontario Canada

N
Natasha Milligan

Department of Obstetrics & Gynecology Mount Sinai Hospital Toronto Ontario Canada

M
Mike Seed

Division of Cardiology Hospital for Sick Children Toronto Ontario Canada; Department of Pediatrics and Diagnostic Imaging University of Toronto Toronto Ontario Canada

J
John G. Sled

Department of Medical Biophysics University of Toronto Toronto Ontario Canada; Mouse Imaging Centre Hospital for Sick Children Toronto Ontario Canada; Department of Obstetrics and Gynecology University of Toronto Toronto Ontario Canada

C
Christopher K. Macgowan

Department of Medical Biophysics University of Toronto Toronto Ontario Canada; Division of Translational Medicine Hospital for Sick Children Toronto Ontario Canada; Labatt Family Heart Centre Hospital for Sick Children Toronto Ontario Canada

Funding
Canadian Institutes of Health Research Award: MOP130403
Cite This Article
Sharon Portnoy, Natasha Milligan, Mike Seed, et al. (2017). Human umbilical cord blood relaxation times and susceptibility at 3 T. Magnetic Resonance in Medicine, 79(6), 3194-3206. https://doi.org/10.1002/mrm.26978
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