Separating fetal and maternal placenta circulations using multiparametric MRI

Andrew Melbourne; Rosalind Aughwane; Magdalena Sokolska; David Owen; Giles Kendall; Dimitra Flouri; Alan Bainbridge; David Atkinson; Jan Deprest; Tom Vercauteren; Anna David; Sebastien Ourselin

doi:10.1002/mrm.27406

journal article Open Access Sep 21, 2018

Separating fetal and maternal placenta circulations using multiparametric MRI

Andrew Melbourne

Rosalind Aughwane Magdalena Sokolska David Owen

Giles Kendall Dimitra Flouri

Alan Bainbridge David Atkinson

Jan Deprest Tom Vercauteren

Anna David Sebastien Ourselin

Magnetic Resonance in Medicine Vol. 81 No. 1 pp. 350-361 · Wiley

View at Publisher Save 10.1002/mrm.27406

Abstract

PurposeThe placenta is a vital organ for the exchange of oxygen, nutrients, and waste products between fetus and mother. The placenta may suffer from several pathologies, which affect this fetal‐maternal exchange, thus the flow properties of the placenta are of interest in determining the course of pregnancy. In this work, we propose a new multiparametric model for placental tissue signal in MRI.MethodsWe describe a method that separates fetal and maternal flow characteristics of the placenta using a 3‐compartment model comprising fast and slowly circulating fluid pools, and a tissue pool is fitted to overlapping multiecho T2 relaxometry and diffusion MRI with low b‐values. We implemented the combined model and acquisition on a standard 1.5 Tesla clinical system with acquisition taking less than 20 minutes.ResultsWe apply this combined acquisition in 6 control singleton placentas. Mean myometrial T2 relaxation time was 123.63 (±6.71) ms. Mean T2 relaxation time of maternal blood was 202.17 (±92.98) ms. In the placenta, mean T2 relaxation time of the fetal blood component was 144.89 (±54.42) ms. Mean ratio of maternal to fetal blood volume was 1.16 (±0.6), and mean fetal blood saturation was 72.93 (±20.11)% across all 6 cases.ConclusionThe novel acquisition in this work allows the measurement of histologically relevant physical parameters, such as the relative proportions of vascular spaces. In the placenta, this may help us to better understand the physiological properties of the tissue in disease.

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35

References

Details

Published: Sep 21, 2018
Vol/Issue: 81(1)
Pages: 350-361
License: View

Authors

A

Andrew Melbourne

Department of Medical Physics and Biomedical Engineering University College London London United Kingdom; School of Biomedical Engineering and Imaging Kings College London, London United Kingdom

R

Rosalind Aughwane

Department of Medical Physics and Biomedical Engineering University College London London United Kingdom; Institute for Women’s Health University College Hospital,London London United Kingdom

M

Magdalena Sokolska

Medical Physics University College Hospital London United Kingdom

D

David Owen

Department of Medical Physics and Biomedical Engineering University College London London United Kingdom; School of Biomedical Engineering and Imaging Kings College London, London United Kingdom

G

Giles Kendall

Institute for Women’s Health University College Hospital,London London United Kingdom

D

Dimitra Flouri

Department of Medical Physics and Biomedical Engineering University College London London United Kingdom; School of Biomedical Engineering and Imaging Kings College London, London United Kingdom

A

Alan Bainbridge

Medical Physics University College Hospital London United Kingdom

D

David Atkinson

Centre for Medical Imaging University College London London United Kingdom

J

Jan Deprest

Institute for Women’s Health University College Hospital,London London United Kingdom; University Hospital KU Leuven Leuven Belgium

T

Tom Vercauteren

Department of Medical Physics and Biomedical Engineering University College London London United Kingdom; School of Biomedical Engineering and Imaging Kings College London, London United Kingdom

A

Anna David

Institute for Women’s Health University College Hospital,London London United Kingdom; University Hospital KU Leuven Leuven Belgium; NIHR University College London Hospitals Biomedical Research Centre London United Kingdom

S

Sebastien Ourselin

Department of Medical Physics and Biomedical Engineering University College London London United Kingdom; School of Biomedical Engineering and Imaging Kings College London, London United Kingdom

Funding

Wellcome Trust Award: 210182/Z/18/Z

Engineering and Physical Sciences Research Council Award: NS/A000027/1

National Institute for Health Research

Cite This Article

Andrew Melbourne, Rosalind Aughwane, Magdalena Sokolska, et al. (2018). Separating fetal and maternal placenta circulations using multiparametric MRI. Magnetic Resonance in Medicine, 81(1), 350-361. https://doi.org/10.1002/mrm.27406

Separating fetal and maternal placenta circulations using multiparametric MRI

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