Origin of orientation‐dependent R1 (=1/T1) relaxation in white matter

Felix Schyboll; Uwe Jaekel; Francesco Petruccione; Heiko Neeb

doi:10.1002/mrm.28277

journal article Open Access Apr 10, 2020

Origin of orientation‐dependent R1 (=1/T1) relaxation in white matter

Felix Schyboll

Uwe Jaekel Francesco Petruccione

Heiko Neeb

Magnetic Resonance in Medicine Vol. 84 No. 5 pp. 2713-2723 · Wiley

View at Publisher Save 10.1002/mrm.28277

Abstract

PurposeIn a recent MRI study, it was shown that the longitudinal relaxation rate, R1, in white matter (WM) is influenced by the relative orientation of nerve fibers with respect to the main magnetic field (B0). Even though the exact nature of this R1 orientation dependency is still unclear, it can be assumed that the origin of the phenomenon can be attributed to the anisotropic and unique molecular environment within the myelin sheath surrounding the axons. The current work investigates the contribution of dipolar induced R1 relaxation of the myelin associated hydrogen nuclei theoretically and compares the results with the experimentally observed R1 orientation dependency.MethodsAtomistic molecular dynamics simulations were employed and the R1 relaxation rate of hydrogen nuclei of a myelin‐alike molecular environment was calculated for various orientations of the trajectory sets relative to the B0‐field. Based on the calculated relaxation rates, the observable R1 relaxation was simulated for various fiber orientations and fitted to the experimental data using a suitable signal weighting‐scheme.ResultsThe results obtained show that the R1 relaxation rate of both solid myelin (SM) and myelin water (MW) depends on the fiber orientation relative to the main B0‐field. Moreover, employing a realistic signal weighing scheme and tissue characteristics, the theoretically investigated R1 orientation dependency matches the experimental data well.ConclusionThe good agreement between theoretical and experimental findings indicates that the R1 orientation dependency in WM mainly originates from anisotropic dipole‐dipole interactions between hydrogen nuclei located within the myelin sheath.

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References

44

[1]

10.1016/j.neuroimage.2010.10.070

[2]

Microstructural and physiological features of tissues elucidated by quantitative-diffusion-tensor MRI

Peter J. Basser, Carlo Pierpaoli

Journal of Magnetic Resonance 10.1016/j.jmr.2011.09.022

[3]

10.1002/mrm.22135

[4]

10.1093/brain/awp007

[5]

10.1016/j.nurt.2007.05.004

[6]

10.1016/s0022-510x(01)00576-7

[7]

10.1038/s41598-019-51003-4

[8]

10.1007/s10334-018-0678-8

[9]

NMR relaxation times in the human brain at 3.0 tesla

Janaka P. Wansapura, Scott K. Holland, R. Scott Dunn et al.

Journal of Magnetic Resonance Imaging 10.1002/(sici)1522-2586(199904)9:4<531::aid-jmri4>3.0.co;2-l

[10]

ChenL BernsteinM HustonJ FainS.Measurements of T1 relaxation times at 3.0 T: Implications for clinical MRA. In: Proceedings of the 9th Annual Meeting of ISMRM.Glasgow Scotland 2001. p1391.

[11]

10.1002/1522-2594(200101)45:1<71::aid-mrm1011>3.0.co;2-2

[12]

10.1073/pnas.80.23.7183

[13]

10.1103/physrev.73.679

[14]

10.1016/0009-3084(67)90023-0

[15]

10.1016/0009-3084(72)90026-6

[16]

10.1016/s0006-3495(91)82286-x

[17]

10.1103/physreve.58.2259

[18]

10.1063/1.468491

[19]

10.1002/nbm.683

[20]

GROMACS 3.0: a package for molecular simulation and trajectory analysis

Erik Lindahl, Berk Hess, David van der Spoel

Journal of Molecular Modeling 10.1007/s008940100045

[21]

CHARMM general force field: A force field for drug‐like molecules compatible with the CHARMM all‐atom additive biological force fields

K. Vanommeslaeghe, E. Hatcher, C. Acharya et al.

Journal of Computational Chemistry 10.1002/jcc.21367

[22]

Building Force Fields: An Automatic, Systematic, and Reproducible Approach

Lee-Ping Wang, Todd J. Martínez, Vijay S. Pande

The Journal of Physical Chemistry Letters 10.1021/jz500737m

[23]

10.1016/s0022-2275(20)35364-5

[24]

10.1002/mrm.1910330406

[25]

10.1002/(sici)1522-2594(199912)42:6<1128::aid-mrm18>3.0.co;2-9

[26]

10.1002/mrm.20680

[27]

10.1002/mrm.22873

[28]

10.1002/mrm.22131

[29]

Morell P "Characteristic composition of myelin" Basic Neurochemistry: Molecular, Cellular and Medical Aspects (1999)

[30]

10.1002/mrm.25729

[31]

Knight MJ "Observation of angular dependence of T1 in the human white matter at 3T" Biomed Spectrosc Imaging (2018)

[32]

Characterization and propagation of uncertainty in diffusion‐weighted MR imaging

T.E.J. Behrens, M.W. Woolrich, M. Jenkinson et al.

Magnetic Resonance in Medicine 10.1002/mrm.10609

[33]

Advances in functional and structural MR image analysis and implementation as FSL

Stephen M. Smith, Mark Jenkinson, Mark W. Woolrich et al.

NeuroImage 10.1016/j.neuroimage.2004.07.051

[34]

10.1073/pnas.0407259102

[35]

10.1016/j.neuroimage.2009.08.039

[36]

10.1002/mrm.21965

[37]

10.1016/j.jmr.2016.05.007

[38]

10.1016/j.jmr.2019.01.013

[39]

10.1002/mrm.27797

[40]

10.1016/j.nicl.2012.09.013

[41]

10.1002/mrm.24571

[42]

10.1016/0009-3084(71)90060-0

[43]

10.1103/physrev.111.1201

[44]

10.1002/mrm.27398

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Details

Published: Apr 10, 2020
Vol/Issue: 84(5)
Pages: 2713-2723
License: View

Authors

F

Felix Schyboll

University of Applied Sciences Koblenz RheinAhrCampus Remagen Germany

U

Uwe Jaekel

University of Applied Sciences Koblenz RheinAhrCampus Remagen Germany

F

Francesco Petruccione

University of KwaZulu‐Natal Centre for Quantum Technology Durban South Africa

H

Heiko Neeb

University of Applied Sciences Koblenz RheinAhrCampus Remagen Germany; Institute for Medical Engineering and Information Processing – MTI Mittelrhein, University of Koblenz Koblenz Germany

Cite This Article

Felix Schyboll, Uwe Jaekel, Francesco Petruccione, et al. (2020). Origin of orientation‐dependent R1 (=1/T1) relaxation in white matter. Magnetic Resonance in Medicine, 84(5), 2713-2723. https://doi.org/10.1002/mrm.28277

Origin of orientation‐dependent R1 (=1/T1) relaxation in white matter

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