Diffusion‐weighted SPECIAL improves the detection of J‐coupled metabolites at ultrahigh magnetic field

Jessie Mosso; Dunja Simicic; Bernard Lanz; Rolf Gruetter; Cristina Cudalbu

doi:10.1002/mrm.29805

journal article Open Access Sep 28, 2023

Diffusion‐weighted SPECIAL improves the detection of J‐coupled metabolites at ultrahigh magnetic field

Jessie Mosso

Dunja Simicic

Bernard Lanz

Rolf Gruetter Cristina Cudalbu

Magnetic Resonance in Medicine Vol. 91 No. 1 pp. 4-18 · Wiley

View at Publisher Save 10.1002/mrm.29805

Abstract

AbstractPurposeTo improve the detection and subsequent estimation of the diffusion properties of strongly J‐coupled metabolites in diffusion‐weighted MRS (DWS).MethodsA new sequence for single‐voxel diffusion‐weighted 1H MR spectroscopy, named DW‐SPECIAL, is proposed. It combines the semi‐adiabatic SPECIAL sequence with a stimulated echo diffusion block. Acquisitions with DW‐SPECIAL and STE‐LASER, the current gold standard for rodent DWS experiments at high fields, were performed at 14.1T on phantoms and in vivo on the rat brain. The apparent diffusion coefficient and intra‐stick diffusivity (Callaghan's model, randomly‐oriented sticks) were fitted and compared between the sequences for glutamate, glutamine, myo‐inositol, taurine, total NAA, total Cho, total Cr, and the macromolecules.ResultsThe shorter TE achieved with DW‐SPECIAL (18 ms against 33 ms with STE‐LASER) substantially limited the metabolites' signal loss caused by J‐evolution. In addition, DW‐SPECIAL preserved the main advantages of STE‐LASER: absence of cross‐terms, diffusion time during a stimulated echo, and limited sensitivity to B1 inhomogeneities. In vivo, compared to STE‐LASER, DW‐SPECIAL yielded the same spectral quality and reduced the Cramer Rao Lower Bounds for J‐coupled metabolites, irrespective of the b‐value. DW‐SPECIAL also reduced the SD of the metabolites' diffusion estimates based on individual animal fitting without loss of accuracy compared to the fit on the averaged decay.ConclusionWe conclude that due to its reduced TE, DW‐SPECIAL can serve as an alternative to STE‐LASER when strongly J‐coupled metabolites like glutamine are investigated, thereby extending the range of accessible metabolites in the context of DWS acquisitions.

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Details

Published: Sep 28, 2023
Vol/Issue: 91(1)
Pages: 4-18
License: View

Authors

J

Jessie Mosso

LIFMET, EPFL Lausanne Switzerland; CIBM Center for Biomedical Imaging Lausanne Switzerland; Animal Imaging and Technology, EPFL Lausanne Switzerland

D

Dunja Simicic

CIBM Center for Biomedical Imaging Lausanne Switzerland; Animal Imaging and Technology, EPFL Lausanne Switzerland

B

Bernard Lanz

CIBM Center for Biomedical Imaging Lausanne Switzerland; Animal Imaging and Technology, EPFL Lausanne Switzerland

R

Rolf Gruetter

LIFMET, EPFL Lausanne Switzerland

C

Cristina Cudalbu

CIBM Center for Biomedical Imaging Lausanne Switzerland; Animal Imaging and Technology, EPFL Lausanne Switzerland

Funding

Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung Award: 310030_173222

H2020 Marie Skłodowska-Curie Actions Award: 813120

Ecole Polytechnique Fédérale de Lausanne

Cite This Article

Jessie Mosso, Dunja Simicic, Bernard Lanz, et al. (2023). Diffusion‐weighted SPECIAL improves the detection of J‐coupled metabolites at ultrahigh magnetic field. Magnetic Resonance in Medicine, 91(1), 4-18. https://doi.org/10.1002/mrm.29805

Diffusion‐weighted SPECIAL improves the detection of J‐coupled metabolites at ultrahigh magnetic field

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