The effects of maternal flow on placental diffusion‐weighted MRI and intravoxel incoherent motion parameters

George Jack Hutchinson; Adam Blakey; Nia Jones; Lopa Leach; Neele Dellschaft; Paul Houston; Matthew Hubbard; Reuben O'Dea; Penny Anne Gowland

doi:10.1002/mrm.30379

journal article Open Access Nov 28, 2024

The effects of maternal flow on placental diffusion‐weighted MRI and intravoxel incoherent motion parameters

George Jack Hutchinson

Adam Blakey Nia Jones Lopa Leach

Neele Dellschaft Paul Houston Matthew Hubbard Reuben O'Dea Penny Anne Gowland

Magnetic Resonance in Medicine Vol. 93 No. 4 pp. 1629-1641 · Wiley

View at Publisher Save 10.1002/mrm.30379

Abstract

AbstractPurposeTo investigate and explain observed features of the placental DWI signal in healthy and compromised pregnancies using a mathematical model of maternal blood flow.MethodsThirteen healthy and nine compromised third trimester pregnancies underwent pulse gradient spin echo DWI MRI, with the results compared to MRI data simulated from a 2D mathematical model of maternal blood flow through the placenta. Both sets of data were fitted to an intravoxel incoherent motion (IVIM) model, and a rebound model (defined within text), which described voxels that did not decay monotonically. Both the in vivo and simulated placentas were split into regions of interest (ROIs) to analyze how the signal varies and how IVIM and rebounding parameters change across the placental width.ResultsThere was good agreement between the in vivo MRI data, and the data simulated from the mathematical model. Both sets of data included voxels showing a rebounding signal and voxels showing fast signal decay focused near the maternal side of the placenta. In vivo we found higher in the uterine wall and near the maternal side of the placenta, with the slow diffusion coefficient reduced in all ROIs in compromised pregnancy.ConclusionA simulation based entirely on maternal blood explains key features observed in placental DWI, indicating the importance of maternal blood flow in interpreting placental MRI data, and providing potential new metrics for understanding changes in compromised placentas.

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Citations

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References

Details

Published: Nov 28, 2024
Vol/Issue: 93(4)
Pages: 1629-1641
License: View

Authors

G

George Jack Hutchinson

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy The University of Nottingham Nottingham UK

A

Adam Blakey

School of Mathematical Sciences The University of Nottingham Nottingham UK

N

Nia Jones

School of Medicine The University of Nottingham Nottingham UK

L

Lopa Leach

School of Life Sciences The University of Nottingham Nottingham UK

N

Neele Dellschaft

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy The University of Nottingham Nottingham UK

P

Paul Houston

School of Mathematical Sciences The University of Nottingham Nottingham UK

M

Matthew Hubbard

School of Mathematical Sciences The University of Nottingham Nottingham UK

R

Reuben O'Dea

School of Mathematical Sciences The University of Nottingham Nottingham UK

P

Penny Anne Gowland

Sir Peter Mansfield Imaging Centre, School of Physics and Astronomy The University of Nottingham Nottingham UK

Funding

National Institutes of Health

Engineering and Physical Sciences Research Council

Wellcome Leap

Cite This Article

George Jack Hutchinson, Adam Blakey, Nia Jones, et al. (2024). The effects of maternal flow on placental diffusion‐weighted MRI and intravoxel incoherent motion parameters. Magnetic Resonance in Medicine, 93(4), 1629-1641. https://doi.org/10.1002/mrm.30379

The effects of maternal flow on placental diffusion‐weighted MRI and intravoxel incoherent motion parameters

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