Cerebellar imaging for neuroscience at 9.4 T

W. van der Zwaag; D. H. Y. Tse; Benedikt A. Poser; N. Priovoulos

doi:10.1002/mrm.30596

journal article Open Access Jun 28, 2025

Cerebellar imaging for neuroscience at 9.4 T

W. van der Zwaag D. H. Y. Tse Benedikt A. Poser

N. Priovoulos

Magnetic Resonance in Medicine Vol. 94 No. 5 pp. 2129-2139 · Wiley

View at Publisher Save 10.1002/mrm.30596

Abstract

AbstractPurposeThis study explored the possibility of visualizing cerebellar structure and function in vivo with a 9.4 T protocol suitable for neuroscientific experiments.MethodsSix healthy individuals were scanned with a 9.4 T acquisition protocol including functional runs using BOLD‐weighted 3D EPI at 0.8 and 1.0 mm isotropic resolution, and a 0.4 mm MP2RAGE covering the entire cerebellum to derive cerebellar cortical surfaces.ResultsScan sessions took approximately 1 h, a duration generally well tolerated in (cognitive) neuroscience experiments. A generalized B1 shim over the cerebellum provided sufficient contrast for gray–white matter segmentation and surface generation in all participants. A motor‐task paradigm yielded consistent responses in both hemispheres in the posterior and anterior cerebellar lobes.ConclusionThese experiments show that it is feasible to undertake neuroscientific experiments in the human cerebellum using 9.4 T MRI. The increased SNR and BOLD sensitivity benefit both structural and functional acquisitions and derivatives such as cortical surfaces generated from these data.

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Details

Published: Jun 28, 2025
Vol/Issue: 94(5)
Pages: 2129-2139
License: View

Authors

W

W. van der Zwaag

Spinoza Centre for Neuroimaging Royal Netherlands Academy for Arts and Sciences Amsterdam The Netherlands; Computational and Cognitive Neuroscience and Neuroimaging, Netherlands Institute for Neuroscience Royal Netherlands Academy for Arts and Sciences Amsterdam The Netherlands

D

D. H. Y. Tse

Scannexus BV Maastricht The Netherlands

B

Benedikt A. Poser

Faculty of Psychology and Neuroscience Maastricht University Maastricht The Netherlands

N

N. Priovoulos

Spinoza Centre for Neuroimaging Royal Netherlands Academy for Arts and Sciences Amsterdam The Netherlands; Department of Biomedical Engineering and Physics, Amsterdam University Medical Centers University of Amsterdam Amsterdam The Netherlands; Oxford Centre for Integrative Neuroimaging, FMRIB, Nuffield Department of Clinical Neurosciences University of Oxford Oxford UK

Funding

Nederlandse Organisatie voor Wetenschappelijk Onderzoek Award: 015.014.038

H2020 European Institute of Innovation and Technology Award: 88587

Amsterdam Brain and Cognition Award: T0922

Cite This Article

W. van der Zwaag, D. H. Y. Tse, Benedikt A. Poser, et al. (2025). Cerebellar imaging for neuroscience at 9.4 T. Magnetic Resonance in Medicine, 94(5), 2129-2139. https://doi.org/10.1002/mrm.30596

Cerebellar imaging for neuroscience at 9.4 T

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