Structure and function of the skeletal muscle extracellular matrix

Allison R. Gillies; Richard L. Lieber

doi:10.1002/mus.22094

journal article Aug 18, 2011

Structure and function of the skeletal muscle extracellular matrix

Allison R. Gillies Richard L. Lieber

Muscle & Nerve Vol. 44 No. 3 pp. 318-331 · Wiley

View at Publisher Save 10.1002/mus.22094

Abstract

AbstractThe skeletal muscle extracellular matrix (ECM) plays an important role in muscle fiber force transmission, maintenance, and repair. In both injured and diseased states, ECM adapts dramatically, a property that has clinical manifestations and alters muscle function. Here we review the structure, composition, and mechanical properties of skeletal muscle ECM; describe the cells that contribute to the maintenance of the ECM; and, finally, overview changes that occur with pathology. New scanning electron micrographs of ECM structure are also presented with hypotheses about ECM structure–function relationships. Detailed structure–function relationships of the ECM have yet to be defined and, as a result, we propose areas for future study. Muscle Nerve 44: 318–331, 2011

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Metrics

864

Citations

137

References

Details

Published: Aug 18, 2011
Vol/Issue: 44(3)
Pages: 318-331
License: View

Authors

Funding

NSF

Department of Veterans Affairs Award: NIH Grant R24HD050837

Cite This Article

Allison R. Gillies, Richard L. Lieber (2011). Structure and function of the skeletal muscle extracellular matrix. Muscle & Nerve, 44(3), 318-331. https://doi.org/10.1002/mus.22094

Structure and function of the skeletal muscle extracellular matrix

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