MRI quantification of non‐Gaussian water diffusion by kurtosis analysis

Jens H. Jensen; Joseph A. Helpern

doi:10.1002/nbm.1518

journal article May 19, 2010

MRI quantification of non‐Gaussian water diffusion by kurtosis analysis

Jens H. Jensen Joseph A. Helpern

NMR in Biomedicine Vol. 23 No. 7 pp. 698-710 · Wiley

View at Publisher Save 10.1002/nbm.1518

Abstract

AbstractQuantification of non‐Gaussianity for water diffusion in brain by means of diffusional kurtosis imaging (DKI) is reviewed. Diffusional non‐Gaussianity is a consequence of tissue structure that creates diffusion barriers and compartments. The degree of non‐Gaussianity is conveniently quantified by the diffusional kurtosis and derivative metrics, such as the mean, axial, and radial kurtoses. DKI is a diffusion‐weighted MRI technique that allows the diffusional kurtosis to be estimated with clinical scanners using standard diffusion‐weighted pulse sequences and relatively modest acquisition times. DKI is an extension of the widely used diffusion tensor imaging method, but requires the use of at least 3 b‐values and 15 diffusion directions. This review discusses the underlying theory of DKI as well as practical considerations related to data acquisition and post‐processing. It is argued that the diffusional kurtosis is sensitive to diffusional heterogeneity and suggested that DKI may be useful for investigating ischemic stroke and neuropathologies, such as Alzheimer's disease and schizophrenia. Copyright © 2010 John Wiley & Sons, Ltd.

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1,140

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References

Details

Published: May 19, 2010
Vol/Issue: 23(7)
Pages: 698-710
License: View

Authors

J

Jens H. Jensen

Center for Biomedical Imaging Medical University of South Carolina Charleston SC; Department of Radiology and Radiological Science Medical University of South Carolina Charleston SC

J

Joseph A. Helpern

Department of Neurology Medical University of South Carolina Charleston SC; Center for Biomedical Imaging Medical University of South Carolina Charleston SC; Department of Radiology and Radiological Science Medical University of South Carolina Charleston SC; Department of Neuroscience Medical University of South Carolina Charleston SC

Cite This Article

Jens H. Jensen, Joseph A. Helpern (2010). MRI quantification of non‐Gaussian water diffusion by kurtosis analysis. NMR in Biomedicine, 23(7), 698-710. https://doi.org/10.1002/nbm.1518

MRI quantification of non‐Gaussian water diffusion by kurtosis analysis

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