Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity

Iris M. Balodis; Nathan D. Molina; Hedy Kober; Patrick D. Worhunsky; Marney A. White; Rajita Sinha; Carlos M. Grilo; Marc N. Potenza

doi:10.1002/oby.20068

journal article Feb 01, 2013

Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity

Iris M. Balodis Nathan D. Molina Hedy Kober

Patrick D. Worhunsky Marney A. White

Rajita Sinha

Carlos M. Grilo

Marc N. Potenza

Obesity Vol. 21 No. 2 pp. 367-377 · Wiley

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Abstract

AbstractObjective:An important endeavor involves increasing our understanding of biobehavioral processes underlying different types of obesity. The current study investigated the neural correlates of cognitive control (involving conflict monitoring and response inhibition) in obese individuals with binge eating disorder (BED) as compared to BMI‐matched non‐BED obese (OB) individuals and lean comparison (LC) participants. Alterations in cognitive control may contribute to differences in behavioral control over eating behaviors in BED and obesity.Design and Methods:Participants underwent functional magnetic resonance imaging while completing the Stroop color‐word interference task.Results and Conclusions:Relative to the OB and LC groups, activity in the BED group was differentiated by relative hypoactivity in brain areas involved in self‐regulation and impulse control. Specifically, the BED group showed diminished activity in the ventromedial prefrontal cortex (vmPFC), inferior frontal gyrus (IFG), and insula during Stroop performance. In addition, dietary restraint scores were negatively correlated with right IFG and vmPFC activation in the BED group, but not in the OB or HC groups. Thus, BED individuals' diminished ability to recruit impulse‐control‐related brain regions appears associated with impaired dietary restraint. The observed differences in neural correlates of inhibitory processing in BED relative to OB and LC groups suggest distinct eurobiological contributions to binge eating as a subgroup of obese individuals.

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Details

Published: Feb 01, 2013
Vol/Issue: 21(2)
Pages: 367-377
License: View

Authors

Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511;

P

Patrick D. Worhunsky

Department of Psychiatry, Yale University School of Medicine, New Haven, CT 06511;

Department of Psychiatry and Department of Psychology, Yale University, New Haven, Connecticut, USA; email: carlos.grilo@yale.edu

M

Marc N. Potenza

Cite This Article

Iris M. Balodis, Nathan D. Molina, Hedy Kober, et al. (2013). Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity. Obesity, 21(2), 367-377. https://doi.org/10.1002/oby.20068

Divergent neural substrates of inhibitory control in binge eating disorder relative to other manifestations of obesity

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