Association Between Gestational Weight Gain and Autism Spectrum Disorder in Offspring: A Meta‐Analysis

Le Su; Cheng Chen; Liping Lu; Anny H. Xiang; Linda Dodds; Ka He

doi:10.1002/oby.22966

journal article Oct 01, 2020

Association Between Gestational Weight Gain and Autism Spectrum Disorder in Offspring: A Meta‐Analysis

Le Su

Cheng Chen

Liping Lu

Anny H. Xiang

Linda Dodds Ka He

Obesity Vol. 28 No. 11 pp. 2224-2231 · Wiley

View at Publisher Save 10.1002/oby.22966

Abstract

ObjectiveThis study aimed to quantitatively examine the association between gestational weight gain (GWG) and risk of autism spectrum disorder (ASD) in offspring.MethodsElectronic databases were searched for studies of excessive or inadequate GWG, as compared with recommended GWG, in relation to the risk of ASD in offspring. Measures of the association from primary studies were pooled using a meta‐analytic approach and expressed as weighted odds ratios (ORs) with 95% CIs.ResultsNine studies were identified, including 323,253 participants with 4,135 cases of ASD from five cohort studies and 1,462 cases and 3,265 controls from four case‐control studies. Evidence from cohort studies indicates that both excessive and inadequate GWG was significantly associated with a higher risk for ASD in offspring. The pooled OR of ASD was 1.10 (95% CI: 1.02‐1.18) for excessive GWG and 1.13 (95% CI: 1.04‐1.24) for inadequate GWG using recommended GWG as the reference. Evidence from case‐control studies suggests that excessive GWG (1.38 [95% CI: 1.19‐1.62]) but not inadequate GWG (0.87 [95% CI: 0.72‐1.04]) was significantly associated with a higher risk for ASD.ConclusionsThe accumulated evidence has supported that gaining weight outside the recommended GWG is associated with a higher risk for ASD in offspring.

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Details

Published: Oct 01, 2020
Vol/Issue: 28(11)
Pages: 2224-2231
License: View

Authors

L

Le Su

Department of Epidemiology and Biostatistics School of Public Health Indiana University Bloomington Indiana USA

C

Cheng Chen

Department of Obstetrics and Gynecology and Department of Epidemiology Columbia University Irving Medical Center New York New York USA

L

Liping Lu

Department of Obstetrics and Gynecology and Department of Epidemiology Columbia University Irving Medical Center New York New York USA

A

Anny H. Xiang

Department of Research and Evaluation Southern California Permanente Medical Group Pasadena California USA

L

Linda Dodds

Perinatal Epidemiology Research Unit Departments of Obstetrics and Gynaecology and Pediatrics Dalhousie University Halifax Nova Scotia Canada

K

Ka He

Department of Obstetrics and Gynecology and Department of Epidemiology Columbia University Irving Medical Center New York New York USA

Funding

National Institutes of Health Award: R01AG056111

Cite This Article

Le Su, Cheng Chen, Liping Lu, et al. (2020). Association Between Gestational Weight Gain and Autism Spectrum Disorder in Offspring: A Meta‐Analysis. Obesity, 28(11), 2224-2231. https://doi.org/10.1002/oby.22966

Association Between Gestational Weight Gain and Autism Spectrum Disorder in Offspring: A Meta‐Analysis

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