Measuring and estimating insulin resistance in clinical and research settings

Amalia Gastaldelli

doi:10.1002/oby.23503

journal article Open Access Jul 27, 2022

Measuring and estimating insulin resistance in clinical and research settings

Amalia Gastaldelli

Obesity Vol. 30 No. 8 pp. 1549-1563 · Wiley

View at Publisher Save 10.1002/oby.23503

Abstract

AbstractThe article discusses how to measure insulin resistance in muscle, liver, and adipose tissue in human participants. The most frequently used methodologies to evaluate insulin resistance are described in detail starting from the gold standard, that is, the euglycemic hyperinsulinemic clamp, to the intravenous glucose tolerance test, surrogate indices based on fasting measurements, or dynamic tests (such as oral glucose or mixed meal tolerance tests). The accuracy, precision, and reproducibility of the tests as well as cutoff values are reported.

Topics

No keywords indexed for this article. Browse by subject →

References

91

[1]

10.1172/jci34275

[2]

10.1016/j.cell.2012.02.017

[3]

10.1152/ajpendo.1979.237.3.e214

[4]

10.1172/jci114142

[5]

10.1016/0026-0495(90)90002-t

[6]

10.2337/dc11-1951

[7]

10.2337/dc05-2445

[8]

10.1111/j.1463-1326.2011.01429.x

[9]

10.1210/jc.2003-031410

[10]

10.1210/jc.2005-0482

[11]

10.2337/dc11-2339

[12]

Wolfe RR (1992)

[13]

10.2337/diabetes.54.2.333

[14]

10.1042/cs19990268

[15]

10.1016/s1262-3636(07)70135-0

[16]

10.2337/diab.36.8.914

[17]

10.1210/jc.2018-01569

[18]

10.1111/j.1464-5491.2011.03406.x

[19]

10.1177/193229680800200521

[20]

10.1177/193229680800200522

[21]

10.1016/j.metabol.2020.154263

[22]

Bergman RN "Toward physiological understanding of glucose tolerance: minimal‐model approach" Diabetes

[23]

10.2337/diab.43.9.1114

[24]

10.1172/jci112886

[25]

10.1152/ajpendo.1998.274.4.e592

[26]

10.1210/edrv-6-1-45

[27]

10.1152/ajpendo.1979.236.6.e667

[28]

10.1152/ajpendo.00656.2009

[29]

10.1007/s00125-017-4340-1

[30]

10.1006/mgme.1997.2658

[31]

10.2337/diacare.24.3.539

[32]

10.1136/gut.2006.107946

[33]

10.2337/diacare.22.9.1462

[34]

10.2337/dc06-1240

[35]

10.2337/diacare.23.3.295

[36]

10.2337/dc07‐0622

[37]

10.1016/s0168-8227(99)00116-3

[38]

10.1152/ajpregu.00291.2016

[39]

10.1210/jc.2014-2299

[40]

10.1016/j.metabol.2013.05.016

[41]

10.1038/ijo.2010.99

[42]

10.1007/s00125-014-3285-x

[43]

10.1016/j.jdiacomp.2020.107731

[44]

10.1007/bf00280883

[45]

10.2337/diacare.21.12.2191

[46]

10.1186/1472‐6823‐13‐47

[47]

10.1371/journal.pone.0154593

[48]

10.1002/(sici)1096-9136(199807)15:7<539::aid-dia668>3.0.co;2-s

[49]

10.1210/jcem.86.10.7902

[50]

10.1038/sj.ijo.0802547

Showing 50 of 91 references

Cited By

187

Association of insulin resistance-related indicators with cardiovascular disease and cardiovascular disease mortality in individuals with MASLD: a population-based study

Xiwen Yang, Wei Peng · 2026

Therapeutic Advances in Endocrinolo...

Estimated glucose disposal rate and the risk of major adverse cardio-cerebrovascular outcomes and mortality in patients undergoing percutaneous coronary intervention: a retrospective cohort study

Shayan Shojaei, Asma Mousavi · 2025

European Journal of Medical Researc...

Muscle Ultrasound Echo Intensity Detects Insulin Resistance Before Changes in HbA 1c or Fasting Glucose, Independent of BMI

Steven B. Soliman, Jacob E. Leuteneker · 2025

Journal of Ultrasound in Medicine

Exploring Insulin Resistance in Adults With Type 1 Diabetes: The Role of the Estimated Glucose Disposal Rate and the Triglyceride Glucose Index

Silvia Angelino, Antonietta Monda · 2025

Diabetes/Metabolism Research and Re...

The interplay of factors in metabolic syndrome: understanding its roots and complexity

Md. Sharifull Islam, Ping Wei · 2024

Molecular Medicine

Effects of Tirzepatide vs Semaglutide on β-Cell Function, Insulin Sensitivity, and Glucose Control During a Meal Test

Kieren J Mather, Andrea Mari · 2024

The Journal of Clinical Endocrinolo...

EASL-EASD-EASO Clinical Practice Guidelines on the Management of Metabolic Dysfunction-Associated Steatotic Liver Disease (MASLD)

· 2024

Obesity Facts

EASL–EASD–EASO Clinical Practice Guidelines on the management of metabolic dysfunction-associated steatotic liver disease (MASLD)

Frank Tacke, Paul Horn · 2024

Journal of Hepatology

Metrics

187

Citations

91

References

Details

Published: Jul 27, 2022
Vol/Issue: 30(8)
Pages: 1549-1563
License: View

Authors

A

Amalia Gastaldelli

National Research Council (CNR) Institute of Clinical Physiology (IFC) Pisa Italy

Funding

H2020 Marie Skłodowska-Curie Actions Award: mtFOIE GRAS No. 734719

Innovative Medicines Initiative Award: SOPHIA No. 875534

Cite This Article

Amalia Gastaldelli (2022). Measuring and estimating insulin resistance in clinical and research settings. Obesity, 30(8), 1549-1563. https://doi.org/10.1002/oby.23503

Measuring and estimating insulin resistance in clinical and research settings

You May Also Like