Effectiveness and tolerability of liraglutide for the management of weight regain following sleeve gastrectomy

Mohammad Jamal; Wafa Qasem; Fatima Hamshari; Carol Dsouza; Nagi Alqallaf; Paul Otiku; Chukwudi A. Nnaji

doi:10.1002/osp4.706

journal article Open Access Aug 22, 2023

Effectiveness and tolerability of liraglutide for the management of weight regain following sleeve gastrectomy

Mohammad Jamal

Wafa Qasem Fatima Hamshari Carol Dsouza Nagi Alqallaf Paul Otiku Chukwudi A. Nnaji

Obesity Science & Practice Vol. 10 No. 1 · Wiley

View at Publisher Save 10.1002/osp4.706

Abstract

AbstractBackgroundThere is currently very little research evidence on the benefits and safety of liraglutide in the management of weight regain or inadequate weight loss following metabolic and bariatric surgery. This study aimed to determine the clinical effectiveness and tolerability of liraglutide as an adjunct therapy for managing weight regain and inadequate weight loss following sleeve gastrectomy (SG).MethodsThis was a retrospective analysis of medical records conducted at a private clinic in Kuwait.ResultsData of 57 post‐SG patients were included in the analysis. The mean (±SD) pre‐treatment weight was 96.12 (29.26) kg. Following a median liraglutide treatment duration of approximately 3 months, the mean post‐treatment weight was 90.19 (26.82) kg. This represents a statistically significant mean weight loss of 5.94 (6.31) kg (p < 0.001), corresponding to a loss of 6.20% of pre‐treatment weight. Patients aged 31–40 years achieved a greater post‐treatment weight loss of 7.63 (7.41) kg, a loss of 7.80%, relative to age groups after treatment (p = 0.047). Patients who tolerated ≥2.4 mg of liraglutide recorded a higher mean weight loss of 8.42 (7.63) kg, a loss of 8.10% (p = 0.010).ConclusionThe use of liraglutide may be an effective adjunct treatment for weight optimization following SG. Maximizing the tolerable dose may yield greater weight reduction.

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Metrics

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Citations

29

References

Details

Published: Aug 22, 2023
Vol/Issue: 10(1)
License: View

Authors

M

Mohammad Jamal

Department of Organ Transplant Health Sciences Center Kuwait University Kuwait City Kuwait; The Clinic Kuwait City Kuwait; Department of Surgery Jaber Hospital Kuwait City Kuwait; Department of Surgery Health Sciences Center Kuwait University Kuwait City Kuwait

W

Wafa Qasem

The Clinic Kuwait City Kuwait; Mubarak Hospital Kuwait City Kuwait

F

Fatima Hamshari

The Clinic Kuwait City Kuwait

C

Carol Dsouza

Department of Surgery Health Sciences Center Kuwait University Kuwait City Kuwait

N

Nagi Alqallaf

Royal College of Surgeons in Ireland Dublin Ireland

P

Paul Otiku

Faculty of Health Sciences Department of Public Health Lira University Lira Uganda

C

Chukwudi A. Nnaji

School of Public Health and Family Medicine University of Cape Town Rondebosch South Africa

Funding

Novo Nordisk

Cite This Article

Mohammad Jamal, Wafa Qasem, Fatima Hamshari, et al. (2023). Effectiveness and tolerability of liraglutide for the management of weight regain following sleeve gastrectomy. Obesity Science & Practice, 10(1). https://doi.org/10.1002/osp4.706

Effectiveness and tolerability of liraglutide for the management of weight regain following sleeve gastrectomy

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