Investigation of drug release from thermo‐ and pH‐sensitive poly(N‐isopropylacrylamide/itaconic acid) copolymeric hydrogels

B. Taşdelen; N. Kayaman‐Apohan; O. Guven; B. M. Baysal

doi:10.1002/pat.505

journal article Aug 31, 2004

Investigation of drug release from thermo‐ and pH‐sensitive poly(N‐isopropylacrylamide/itaconic acid) copolymeric hydrogels

B. Taşdelen N. Kayaman‐Apohan O. Guven B. M. Baysal

Polymers for Advanced Technologies Vol. 15 No. 9 pp. 528-532 · Wiley

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Abstract

AbstractN‐Isopropylacrylamide/itaconic acid copolymeric hydrogels were prepared by irradiation of the ternary mixtures of N‐isopropylacrylamide/itaconic acid/water by γ‐rays at ambient temperature. The dependence of swelling properties and phase transitions on the comonomer concentration and temperature were investigated. The hydrogels showed both temperature and pH responses. The effect of comonomer concentration on the uptake and release behavior of the hydrogels was studied. Methylene blue (MB) was used as a model drug for the investigation of drug uptake and release behavior of the hydrogels. The release studies showed that the basic parameters affecting the drug release behavior of the hydrogels were pH and temperature of the solution. Copyright © 2004 John Wiley & Sons, Ltd.

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Metrics

21

Citations

12

References

Details

Published: Aug 31, 2004
Vol/Issue: 15(9)
Pages: 528-532
License: View

Authors

Cite This Article

B. Taşdelen, N. Kayaman‐Apohan, O. Guven, et al. (2004). Investigation of drug release from thermo‐ and pH‐sensitive poly(N‐isopropylacrylamide/itaconic acid) copolymeric hydrogels. Polymers for Advanced Technologies, 15(9), 528-532. https://doi.org/10.1002/pat.505

Investigation of drug release from thermo‐ and pH‐sensitive poly(N‐isopropylacrylamide/itaconic acid) copolymeric hydrogels

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