Biodegradable highly porous interconnected poly(ε‐caprolactone)/poly(L‐lactide‐co‐ε‐caprolactone) scaffolds by supercritical foaming for small‐diameter vascular tissue engineering

Yankun Cao; Jing Jiang; Yufan Jiang; Zoe Li; Jianhua Hou; Qian Li

doi:10.1002/pat.5528

journal article Oct 12, 2021

Biodegradable highly porous interconnected poly(ε‐caprolactone)/poly(L‐lactide‐co‐ε‐caprolactone) scaffolds by supercritical foaming for small‐diameter vascular tissue engineering

Yankun Cao Jing Jiang

Yufan Jiang Zoe Li Jianhua Hou

Qian Li

Polymers for Advanced Technologies Vol. 33 No. 1 pp. 440-451 · Wiley

View at Publisher Save 10.1002/pat.5528

Abstract

AbstractBiodegradable ϕ4 mm tubular porous poly(ε‐caprolactone)/poly(L‐lactide‐co‐ε‐caprolactone) (PCL/PLCL) scaffolds are fabricated successfully via one‐step microcellular supercritical carbon dioxide foaming process. The effect of blending ratio on the rheology, pore structures, mechanical property, wettability, and biocompatibility of PCL/PLCL blends tubular scaffold are reported. Rheological results show that PCL matrix and PLCL dispersed phase has good compatibility. The melt strength of PCL can be enhanced obviously by adding PLCL. With an increase of PLCL content from 10 to 30 wt%, the pore size increases from 7.6 to 24.9 μm due to the homogeneous nucleation effect. The maximum open‐cell content can reach 77% for PCL/PLCL foamed sample. Cyclical tensile and compliance tests show that few content of dispersed PLCL (10–20 wt%) improves the flexibility and recoverability. Cell viability results demonstrate that human umbilical vein endothelial cells (HUVECs) cultured on all PCL/PLCL porous scaffolds exhibit a typical spindle‐like cell morphology. Moreover, HUVECs have a higher density and spreading areas on surface of 10% PLCL scaffold. The results gathered in this paper may open a new perspective for the fabrication of small‐diameter vascular tissue engineering scaffold.

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References

Details

Published: Oct 12, 2021
Vol/Issue: 33(1)
Pages: 440-451
License: View

Authors

Y

Yankun Cao

School of Materials Science & Engineering Zhengzhou University Zhengzhou China; National Center for International Joint Research of Micro‐Nano Molding Technology Zhengzhou University Zhengzhou China

J

Jing Jiang

National Center for International Joint Research of Micro‐Nano Molding Technology Zhengzhou University Zhengzhou China; School of Mechanical & Power Engineering Zhengzhou University Zhengzhou China

Y

Yufan Jiang

School of Materials Science & Engineering Zhengzhou University Zhengzhou China; National Center for International Joint Research of Micro‐Nano Molding Technology Zhengzhou University Zhengzhou China

Z

Zoe Li

National Center for International Joint Research of Micro‐Nano Molding Technology Zhengzhou University Zhengzhou China

J

Jianhua Hou

National Center for International Joint Research of Micro‐Nano Molding Technology Zhengzhou University Zhengzhou China

Q

Qian Li

School of Materials Science & Engineering Zhengzhou University Zhengzhou China; National Center for International Joint Research of Micro‐Nano Molding Technology Zhengzhou University Zhengzhou China

Funding

International Science and Technology Cooperation Programme

Cite This Article

Yankun Cao, Jing Jiang, Yufan Jiang, et al. (2021). Biodegradable highly porous interconnected poly(ε‐caprolactone)/poly(L‐lactide‐co‐ε‐caprolactone) scaffolds by supercritical foaming for small‐diameter vascular tissue engineering. Polymers for Advanced Technologies, 33(1), 440-451. https://doi.org/10.1002/pat.5528

Biodegradable highly porous interconnected poly(ε‐caprolactone)/poly(L‐lactide‐co‐ε‐caprolactone) scaffolds by supercritical foaming for small‐diameter vascular tissue engineering

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