Renal ACE2 expression in human kidney disease

AT Lely; I Hamming; H van Goor; GJ Navis

doi:10.1002/path.1670

journal article Nov 10, 2004

Renal ACE2 expression in human kidney disease

AT Lely I Hamming H van Goor GJ Navis

The Journal of Pathology Vol. 204 No. 5 pp. 587-593 · Wiley

View at Publisher Save 10.1002/path.1670

Abstract

AbstractAngiotensin‐converting enzyme 2 (ACE2) is a recently discovered homologue of angiotensin‐converting enzyme (ACE) that is thought to counterbalance ACE. ACE2 cleaves angiotensin I and angiotensin II into the inactive angiotensin 1–9, and the vasodilator and anti‐proliferative angiotensin 1–7, respectively. ACE2 is known to be present in human kidney, but no data on renal disease are available to date. Renal biopsies from 58 patients with diverse primary and secondary renal diseases were studied (hypertensive nephropathy n = 5, IgA glomerulopathy n = 8, minimal change nephropathy n = 7, diabetic nephropathy n = 8, focal glomerulosclerosis n = 5, vasculitis n = 7, and membranous glomerulopathy n = 18) in addition to 17 renal transplants and 18 samples from normal renal tissue. Immunohistochemical staining for ACE2 was scored semi‐quantitatively. In control kidneys, ACE2 was present in tubular and glomerular epithelium and in vascular smooth muscle cells and the endothelium of interlobular arteries. In all primary and secondary renal diseases, and renal transplants, neo‐expression of ACE2 was found in glomerular and peritubular capillary endothelium. There were no differences between the various renal disorders, or between acute and chronic rejection and control transplants. ACE inhibitor treatment did not alter ACE2 expression. In primary and secondary renal disease, and in transplanted kidneys, neo‐expression of ACE2 occurs in glomerular and peritubular capillary endothelium. Further studies should elucidate the possible protective mechanisms involved in the de novo expression of ACE2 in renal disease. Copyright © 2004 Pathological Society of Great Britain and Ireland. Published by John Wiley & Sons, Ltd.

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Published: Nov 10, 2004
Vol/Issue: 204(5)
Pages: 587-593
License: View

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Cite This Article

AT Lely, I Hamming, H van Goor, et al. (2004). Renal ACE2 expression in human kidney disease. The Journal of Pathology, 204(5), 587-593. https://doi.org/10.1002/path.1670

Renal ACE2 expression in human kidney disease

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