Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights

Ariadna Martin‐Blazquez; Angeles Heredero; Gonzalo Aldamiz‐Echevarria; Marta Martin‐Lorenzo; Gloria Alvarez‐Llamas

doi:10.1002/path.5683

journal article Open Access May 24, 2021

Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights

Ariadna Martin‐Blazquez

Angeles Heredero Gonzalo Aldamiz‐Echevarria

Marta Martin‐Lorenzo

Gloria Alvarez‐Llamas

The Journal of Pathology Vol. 254 No. 3 pp. 229-238 · Wiley

View at Publisher Save 10.1002/path.5683

Abstract

AbstractThoracic aortic aneurysm (TAA) develops silently and asymptomatically and is a major cause of mortality. TAA prevalence is greatly underestimated, it is usually diagnosed incidentally, and its treatment consists mainly of prophylactic surgery based on the aortic diameter. The lack of effective drugs and biological markers to identify and stratify TAAs by risk before visible symptoms results from scant knowledge of its pathophysiological mechanisms. Here we integrate the structural impairment affecting non‐syndromic non‐familial TAA with the main cellular and molecular changes described so far and consider how these changes are interconnected through specific pathways. The ultimate goal is to define much‐needed novel markers of TAA, and so the potential of previously identified molecules to aid in early diagnosis/prognosis is also discussed. © 2021 The Authors. The Journal of Pathology published by John Wiley & Sons, Ltd. on behalf of The Pathological Society of Great Britain and Ireland.

Topics

No keywords indexed for this article. Browse by subject →

References

85

[1]

10.1161/circresaha.118.312436

[2]

10.1016/j.jvs.2012.04.053

[3]

10.1016/j.jacc.2009.08.084

[4]

10.1161/circulationaha.114.010890

[5]

10.1016/j.ejvs.2016.01.017

[6]

10.1161/hypertensionaha.118.11851

[7]

2014 ESC Guidelines on the diagnosis and treatment of aortic diseases

European Heart Journal 10.1093/eurheartj/ehu281

[8]

10.1016/j.jtcvs.2014.05.051

[9]

10.1016/j.amjcard.2011.11.038

[10]

10.1016/j.amjcard.2013.05.081

[11]

10.2217/fca-2020-0062

[12]

10.1016/j.jacc.2017.11.005

[13]

10.1097/hjh.0000000000001961

[14]

Structure of the Elastin-Contractile Units in the Thoracic Aorta and How Genes That Cause Thoracic Aortic Aneurysms and Dissections Disrupt This Structure

Ashkan Karimi, Dianna M. Milewicz

Canadian Journal of Cardiology 10.1016/j.cjca.2015.11.004

[15]

10.1016/bs.apha.2017.08.002

[16]

10.1161/circresaha.114.304936

[17]

10.3389/fphys.2017.00938

[18]

Malashicheva A "Phenotypic and functional changes of endothelial and smooth muscle cells in thoracic aortic aneurysms" Int J Vasc Med (2016)

[19]

10.3389/fcvm.2018.00124

[20]

10.1016/j.stemcr.2017.04.028

[21]

10.1093/cvr/cvs298

[22]

10.1007/s00059-019-4786-7

[23]

10.1016/j.jtcvs.2007.12.063

[24]

10.1038/s41598-019-51885-4

[25]

10.1038/nm1099

[26]

10.1093/cvr/cvu196

[27]

10.5772/intechopen.77115

[28]

Cellular Mechanotransduction: From Tension to Function

Fabiana Martino, Ana R. Perestrelo, Vladimír Vinarský et al.

Frontiers in Physiology 10.3389/fphys.2018.00824

[29]

10.1152/physrev.00037.2018

[30]

10.1371/journal.pone.0213794

[31]

10.1007/s10439-011-0372-8

[32]

10.1161/atvbaha.119.312787

[33]

10.1111/apha.12725

[34]

10.18632/oncotarget.16448

[35]

10.1177/2047487318759119

[36]

10.1371/journal.pone.0176727

[37]

10.1093/cvr/cvq224

[38]

10.1159/000151766

[39]

10.5090/kjtcs.2011.44.6.406

[40]

10.1159/000320358

[41]

10.1161/atvbaha.118.311282

[42]

10.1016/s0008-6363(03)00523-6

[43]

10.1152/ajpcell.2001.280.1.c53

[44]

10.1093/cvr/cvt205

[45]

10.1016/j.ajpath.2014.05.014

[46]

10.1016/j.redox.2014.12.007

[47]

10.1002/jcp.22709

[48]

10.1016/j.cardiores.2005.08.002

[49]

10.1016/j.matbio.2019.07.004

[50]

10.1016/j.athoracsur.2009.04.030

Showing 50 of 85 references

Metrics

17

Citations

85

References

Details

Published: May 24, 2021
Vol/Issue: 254(3)
Pages: 229-238
License: View

Authors

A

Ariadna Martin‐Blazquez

Department of Immunology IIS‐Fundación Jiménez Díaz, UAM Madrid Spain

A

Angeles Heredero

Department of Cardiac Surgery Fundación Jiménez Díaz, UAM Madrid Spain

G

Gonzalo Aldamiz‐Echevarria

Department of Cardiac Surgery Fundación Jiménez Díaz, UAM Madrid Spain

M

Marta Martin‐Lorenzo

Department of Immunology IIS‐Fundación Jiménez Díaz, UAM Madrid Spain

G

Gloria Alvarez‐Llamas

Department of Immunology IIS‐Fundación Jiménez Díaz, UAM Madrid Spain; REDInREN Madrid Spain

Cite This Article

Ariadna Martin‐Blazquez, Angeles Heredero, Gonzalo Aldamiz‐Echevarria, et al. (2021). Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights. The Journal of Pathology, 254(3), 229-238. https://doi.org/10.1002/path.5683

Non‐syndromic thoracic aortic aneurysm: cellular and molecular insights

You May Also Like