Temsirolimus for metastatic desmoplastic small round cell tumor

Anna M.J. Thijs; Winette T.A. van der Graaf; Carla M.L. van Herpen

doi:10.1002/pbc.22755

journal article Aug 20, 2010

Temsirolimus for metastatic desmoplastic small round cell tumor

Anna M.J. Thijs Winette T.A. van der Graaf Carla M.L. van Herpen

Pediatric Blood & Cancer Vol. 55 No. 7 pp. 1431-1432 · Wiley

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Abstract

AbstractDesmoplastic small round cell tumor (DSRCT) is a rare and aggressive neoplasm that mostly occurs in young males. No curative treatment options currently exist for this type of tumor and long‐term survival remains poor. In vitro rapamycin induces apoptotic death of JN‐DSRCT‐1 cells, a possible model for desmoplastic small round cell tumors in which the EWS gene is fused to the WT1 gene. We therefore demonstrate the prolonged activity of temsirolimus, an mTOR‐inhibitor, in a patient with DSRCT. Pediatr Blood Cancer. 2010;55:1431–1432. © 2010 Wiley‐Liss, Inc.

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Citations

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Details

Published: Aug 20, 2010
Vol/Issue: 55(7)
Pages: 1431-1432
License: View

Authors

A

Anna M.J. Thijs

W

Winette T.A. van der Graaf

C

Carla M.L. van Herpen

Cite This Article

Anna M.J. Thijs, Winette T.A. van der Graaf, Carla M.L. van Herpen (2010). Temsirolimus for metastatic desmoplastic small round cell tumor. Pediatric Blood & Cancer, 55(7), 1431-1432. https://doi.org/10.1002/pbc.22755

Temsirolimus for metastatic desmoplastic small round cell tumor

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