Multidisciplinary management of hepatoblastoma in children: Experience from a developing country

Naresh Shanmugam; Julius Xavier Scott; Vimal Kumar; Mukul Vij; Priya Ramachandran; Gomathy Narasimhan; Mettu Srinivas Reddy; Venugopal Kota; Deenadayalan Munirathnam; Chayarani Kelgeri; Karthick Sundaram; Mohamed Rela

doi:10.1002/pbc.26249

journal article Oct 26, 2016

Multidisciplinary management of hepatoblastoma in children: Experience from a developing country

Naresh Shanmugam Julius Xavier Scott Vimal Kumar

Mukul Vij

Priya Ramachandran Gomathy Narasimhan Mettu Srinivas Reddy Venugopal Kota Deenadayalan Munirathnam Chayarani Kelgeri Karthick Sundaram Mohamed Rela

Pediatric Blood & Cancer Vol. 64 No. 3 · Wiley

View at Publisher Save 10.1002/pbc.26249

Abstract

AbstractBackgroundAdvances in chemotherapy, liver resection techniques, and pediatric liver transplantation have vastly improved survival in children with hepatoblastoma (HB). These are best managed by a multidisciplinary team (MDT) in a setting where all treatment options are available. Until recently, this was difficult to achieve in India.MethodsAll children (<16 years) with HB treated in a pediatric liver surgery and transplantation unit between January 2011 and July 2016 were reviewed. Data regarding the clinical presentation, preoperative management, surgical treatment, postoperative course, and outcomes were extracted from a prospectively managed database.ResultsThirty children were treated for HB during the study period. Nine children were PRETEXT 4, 7 were PRETEXT 3, 13 were PRETEXT 2, and 1 was PRETEXT 1 (where PRETEXT is pretreatment extension). All children received a neoadjuvant chemotherapy before surgery followed by an adjuvant chemotherapy. Nineteen children had complete resection, while six underwent primary living donor liver transplantation. There were six mortalities including five children who poorly responded to chemotherapy with progressive tumor extension. At a median follow‐up of 30 months, two children who underwent resection and one child who underwent liver transplant had disease recurrence.ConclusionImproved outcomes can be achieved in children with HB even in countries with limited resources when they are managed by MDTs with expertise in pediatric oncology, liver resection, and liver transplantation.

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Details

Published: Oct 26, 2016
Vol/Issue: 64(3)
License: View

Authors

N

Naresh Shanmugam

Department of Pediatric Gastroenterology, Hepatology and Nutrition Global Health City Chennai Tamil Nadu India

J

Julius Xavier Scott

Department of Pediatric Hematology and Oncology Global Health City Chennai Tamil Nadu India

V

Vimal Kumar

Department of Pediatric Hematology and Oncology Global Health City Chennai Tamil Nadu India

M

Mukul Vij

Department of Histopathology Global Health City Chennai Tamil Nadu India

P

Priya Ramachandran

Institute of Liver Diseases & Transplantation Global Health City Chennai Tamil Nadu India

G

Gomathy Narasimhan

Institute of Liver Diseases & Transplantation Global Health City Chennai Tamil Nadu India

M

Mettu Srinivas Reddy

Institute of Liver Diseases & Transplantation Global Health City Chennai Tamil Nadu India

V

Venugopal Kota

Institute of Liver Diseases & Transplantation Global Health City Chennai Tamil Nadu India

D

Deenadayalan Munirathnam

Department of Histopathology Global Health City Chennai Tamil Nadu India

C

Chayarani Kelgeri

Department of Pediatric Gastroenterology, Hepatology and Nutrition Global Health City Chennai Tamil Nadu India

K

Karthick Sundaram

Department of Pediatric Gastroenterology, Hepatology and Nutrition Global Health City Chennai Tamil Nadu India

M

Mohamed Rela

Department of Pediatric Gastroenterology, Hepatology and Nutrition Global Health City Chennai Tamil Nadu India

Cite This Article

Naresh Shanmugam, Julius Xavier Scott, Vimal Kumar, et al. (2016). Multidisciplinary management of hepatoblastoma in children: Experience from a developing country. Pediatric Blood & Cancer, 64(3). https://doi.org/10.1002/pbc.26249

Multidisciplinary management of hepatoblastoma in children: Experience from a developing country

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