Molecular characterization and multidisciplinary management of Gerbich hemolytic disease of the newborn

Rebecca N. Levitt; Elise Gourri; Christoph Gaßner; Grace Banez‐Sese; Abdus Salam; Gregory A. Denomme; Elizabeth Yang

doi:10.1002/pbc.27014

journal article Feb 22, 2018

Molecular characterization and multidisciplinary management of Gerbich hemolytic disease of the newborn

Rebecca N. Levitt Elise Gourri Christoph Gaßner

Grace Banez‐Sese Abdus Salam

Gregory A. Denomme

Elizabeth Yang

Pediatric Blood & Cancer Vol. 65 No. 6 · Wiley

View at Publisher Save 10.1002/pbc.27014

Abstract

AbstractGerbich (Ge) antigens are high frequency red cell antigens expressed on glycophorin C (GYPC) and glycophorin D. Hemolytic disease of the fetus and newborn (HDFN) due to Gerbich antibody is rare and presents a clinical challenge, as Gerbich negative blood is scarce. We report a case of HDFN due to maternal Ge3 negative phenotype and anti‐Ge3 alloimmunization, successfully managed by transfusion of maternal blood. Molecular testing revealed that the mother has homozygous deletion of exon 3 of GYPC, the father is homozygous wildtype for GYPC, and the infant is obligate heterozygote expressing Ge3.

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Citations

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References

Details

Published: Feb 22, 2018
Vol/Issue: 65(6)
License: View

Authors

R

Rebecca N. Levitt

Department of Pediatrics Inova Children's Hospital Falls Church Virginia

E

Elise Gourri

Blood Transfusion Service Zurich Swiss Red Cross (SRC) Zürich‐Schlieren Switzerland

C

Christoph Gaßner

Blood Transfusion Service Zurich Swiss Red Cross (SRC) Zürich‐Schlieren Switzerland

G

Grace Banez‐Sese

Inova Schar Cancer Institute Apheresis Service, Inova Blood Donor Services Inova Donor Services Sterling Virginia

A

Abdus Salam

Blood Bank and Transfusion Service Inova Fairfax Hospital Falls Church Virginia

G

Gregory A. Denomme

Diagnostic laboratories BloodCenter of Wisconsin Milwaukee Wisconsin

E

Elizabeth Yang

Department of Hematology‐Oncology Pediatric Specialists of Virginia Falls Church Virginia; Department of Pediatrics George Washington University School of Medicine Washington District of Columbia; Virginia Commonwealth University School of Medicine—Inova Campus Falls Church Virginia

Cite This Article

Rebecca N. Levitt, Elise Gourri, Christoph Gaßner, et al. (2018). Molecular characterization and multidisciplinary management of Gerbich hemolytic disease of the newborn. Pediatric Blood & Cancer, 65(6). https://doi.org/10.1002/pbc.27014

Molecular characterization and multidisciplinary management of Gerbich hemolytic disease of the newborn

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