Advanced paternal age, infertility, and reproductive risks: A review of the literature

Justin S. Brandt; Mayra A. Cruz Ithier; Todd Rosen; Elena Ashkinadze

doi:10.1002/pd.5402

journal article Jan 01, 2019

Advanced paternal age, infertility, and reproductive risks: A review of the literature

Justin S. Brandt

Mayra A. Cruz Ithier Todd Rosen Elena Ashkinadze

Prenatal Diagnosis Vol. 39 No. 2 pp. 81-87 · Wiley

View at Publisher Save 10.1002/pd.5402

Abstract

AbstractAdvanced paternal age (APA) is associated with infertility and other reproductive risks. Studies looking at APA and outcomes have used different paternal age cut‐offs, which has complicated systematic evaluations of reproductive risk associated with paternal aging. This review of the literature suggests that the impact of paternal aging on adverse reproductive outcomes is small, but significant. Studies suggest the incidence of paternal age effect disorders attributed to de novo autosomal dominant mutations is less than 0.5%. Other risks associated with APA include infertility, miscarriage, birth defects, poor neurodevelopmental outcomes, and childhood cancer. Although the increasing prevalence of APA has mirrored the rise in maternal age, this topic has not received similar attention. In this review, we summarize the available literature on the reproductive risks associated with APA to provide a framework for comprehensive genetic counseling and evidence‐based management of APA pregnancies.

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Details

Published: Jan 01, 2019
Vol/Issue: 39(2)
Pages: 81-87
License: View

Authors

J

Justin S. Brandt

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey

M

Mayra A. Cruz Ithier

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey

T

Todd Rosen

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey

E

Elena Ashkinadze

Department of Obstetrics, Gynecology, and Reproductive Sciences, Division of Maternal Fetal Medicine Rutgers Robert Wood Johnson Medical School New Brunswick New Jersey

Cite This Article

Justin S. Brandt, Mayra A. Cruz Ithier, Todd Rosen, et al. (2019). Advanced paternal age, infertility, and reproductive risks: A review of the literature. Prenatal Diagnosis, 39(2), 81-87. https://doi.org/10.1002/pd.5402

Advanced paternal age, infertility, and reproductive risks: A review of the literature

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