Quantitative signal detection using spontaneous ADR reporting

A. Bate; S. J. W. Evans

doi:10.1002/pds.1742

journal article Apr 08, 2009

Quantitative signal detection using spontaneous ADR reporting

A. Bate S. J. W. Evans

Pharmacoepidemiology and Drug Safety Vol. 18 No. 6 pp. 427-436 · Wiley

View at Publisher Save 10.1002/pds.1742

Abstract

AbstractQuantitative methods are increasingly used to analyse spontaneous reports. We describe the core concepts behind the most common methods, the proportional reporting ratio (PRR), reporting odds ratio (ROR), information component (IC) and empirical Bayes geometric mean (EBGM). We discuss the role of Bayesian shrinkage in screening spontaneous reports, the importance of changes over time in screening the properties of the measures. Additionally we discuss three major areas of controversy and ongoing research: stratification, method evaluation and implementation. Finally we give some suggestions as to where emerging research is likely to lead. Copyright © 2009 John Wiley & Sons, Ltd.

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Details

Published: Apr 08, 2009
Vol/Issue: 18(6)
Pages: 427-436
License: View

Authors

Cite This Article

A. Bate, S. J. W. Evans (2009). Quantitative signal detection using spontaneous ADR reporting. Pharmacoepidemiology and Drug Safety, 18(6), 427-436. https://doi.org/10.1002/pds.1742

Quantitative signal detection using spontaneous ADR reporting

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