Biodegradable polymers applied in tissue engineering research: a review

Monique Martina; Dietmar W Hutmacher

doi:10.1002/pi.2108

journal article Oct 13, 2006

Biodegradable polymers applied in tissue engineering research: a review

Monique Martina Dietmar W Hutmacher

Polymer International Vol. 56 No. 2 pp. 145-157 · Wiley

View at Publisher Save 10.1002/pi.2108

Abstract

AbstractTypical applications and research areas of polymeric biomaterials include tissue replacement, tissue augmentation, tissue support, and drug delivery. In many cases the body needs only the temporary presence of a device/biomaterial, in which instance biodegradable and certain partially biodegradable polymeric materials are better alternatives than biostable ones. Recent treatment concepts based on scaffold‐based tissue engineering principles differ from standard tissue replacement and drug therapies as the engineered tissue aims not only to repair but also regenerate the target tissue. Cells have been cultured outside the body for many years; however, it has only recently become possible for scientists and engineers to grow complex three‐dimensional tissue grafts to meet clinical needs. New generations of scaffolds based on synthetic and natural polymers are being developed and evaluated at a rapid pace, aimed at mimicking the structural characteristics of natural extracellular matrix. This review focuses on scaffolds made of more recently developed synthetic polymers for tissue engineering applications. Currently, the design and fabrication of biodegradable synthetic scaffolds is driven by four material categories: (i) common clinically established polymers, including polyglycolide, polylactides, polycaprolactone; (ii) novel di‐ and tri‐block polymers; (iii) newly synthesized or studied polymeric biomaterials, such as polyorthoester, polyanhydrides, polyhydroxyalkanoate, polypyrroles, poly(ether ester amide)s, elastic shape‐memory polymers; and (iv) biomimetic materials, supramolecular polymers formed by self‐assembly, and matrices presenting distinctive or a variety of biochemical cues. This paper aims to review the latest developments from a scaffold material perspective, mainly pertaining to categories (ii) and (iii) listed above. Copyright © 2006 Society of Chemical Industry

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Details

Published: Oct 13, 2006
Vol/Issue: 56(2)
Pages: 145-157
License: View

Authors

Cite This Article

Monique Martina, Dietmar W Hutmacher (2006). Biodegradable polymers applied in tissue engineering research: a review. Polymer International, 56(2), 145-157. https://doi.org/10.1002/pi.2108

Biodegradable polymers applied in tissue engineering research: a review

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