Anticancer activity of limonoid from Khaya senegalensis

Xi Wang; Feng Chen; Xiao M. Androulakis; Michael J. Wargovich

doi:10.1002/ptr.2148

journal article Jul 17, 2007

Anticancer activity of limonoid from Khaya senegalensis

Xi Wang

Feng Chen

Xiao M. Androulakis Michael J. Wargovich

Phytotherapy Research Vol. 21 No. 8 pp. 731-734 · Wiley

View at Publisher Save 10.1002/ptr.2148

Abstract

AbstractTwo limonoids were isolated from the methanol extract of Khaya senegalensis (Meliaceae), and their structures were identified as 3α,7α‐dideacetylkhivorin (1) and 1‐O‐acetylkhayanolide B (2) on the basis of MS and NMR spectral data. Complete assignments of 1H and 13C chemical shifts for compounds 1 and 2 were achieved by means of 1D and 2D NMR including DEPT, 1H‐1H COSY, HMQC, HMBC experiments. Compound 1 showed significant growth inhibitory activities against MCF‐7, SiHa and Caco‐2 cells with IC50 values in the range of 0.07–0.14 µm (35–69 ppm) while compound 2 did not. Copyright © 2007 John Wiley & Sons, Ltd.

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References

Details

Published: Jul 17, 2007
Vol/Issue: 21(8)
Pages: 731-734
License: View

Authors

X

Xi Wang

China Academy of Space Technology

F

Feng Chen

Changchun University of Science and Technology

Cite This Article

Xi Wang, Feng Chen, Xiao M. Androulakis, et al. (2007). Anticancer activity of limonoid from Khaya senegalensis. Phytotherapy Research, 21(8), 731-734. https://doi.org/10.1002/ptr.2148

Anticancer activity of limonoid from Khaya senegalensis

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