Puerarin: A Review of Pharmacological Effects

Yan‐Xi Zhou; Hong Zhang; Cheng Peng

doi:10.1002/ptr.5083

journal article Dec 13, 2013

Puerarin: A Review of Pharmacological Effects

Yan‐Xi Zhou Hong Zhang

Cheng Peng

Phytotherapy Research Vol. 28 No. 7 pp. 961-975 · Wiley

View at Publisher Save 10.1002/ptr.5083

Abstract

Puerarin is the major bioactive ingredient isolated from the root of the Pueraria lobata (Willd.) Ohwi, which is well known as Gegen (Chinese name) in traditional Chinese medicine. As the most abundant secondary metabolite, puerarin was isolated from Gegen in the late 1950s. Since then, its pharmacological properties have been extensively investigated. It is available in common foods and is used in alternative medicine. It has been widely used in the treatment of cardiovascular and cerebrovascular diseases, diabetes and diabetic complications, osteonecrosis, Parkinson's disease, Alzheimer's disease, endometriosis, and cancer. The beneficial effects of puerarin on the various medicinal purposes may be due to its wide spectrum of pharmacological properties such as vasodilation, cardioprotection, neuroprotection, antioxidant, anticancer, antiinflammation, alleviating pain, promoting bone formation, inhibiting alcohol intake, and attenuating insulin resistance. However, the direct molecular mechanisms and targets remain unclear. This review provides a comprehensive summary of the pharmacological effects of puerarin. Copyright © 2013 John Wiley & Sons, Ltd.

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Details

Published: Dec 13, 2013
Vol/Issue: 28(7)
Pages: 961-975
License: View

Authors

Y

Yan‐Xi Zhou

Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education, Pharmacy College Chengdu University of Traditional Chinese Medicine Chengdu 610075 PR China; Department of Medicinal Botany, School of Pharmacy Second Military Medical University Shanghai 200433 PR China

H

Hong Zhang

Department of Medicinal Botany, School of Pharmacy Second Military Medical University Shanghai 200433 PR China

C

Cheng Peng

Key Laboratory of Standardization of Chinese Herbal Medicines of Ministry of Education, Pharmacy College Chengdu University of Traditional Chinese Medicine Chengdu 610075 PR China

Cite This Article

Yan‐Xi Zhou, Hong Zhang, Cheng Peng (2013). Puerarin: A Review of Pharmacological Effects. Phytotherapy Research, 28(7), 961-975. https://doi.org/10.1002/ptr.5083

Puerarin: A Review of Pharmacological Effects

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