Quercetin and its derivates as antiviral potentials: A comprehensive review

Amalia Di Petrillo; Germano Orrù; Antonella Fais; Massimo C. Fantini

doi:10.1002/ptr.7309

journal article Oct 28, 2021

Quercetin and its derivates as antiviral potentials: A comprehensive review

Amalia Di Petrillo

Germano Orrù Antonella Fais

Massimo C. Fantini

Phytotherapy Research Vol. 36 No. 1 pp. 266-278 · Wiley

View at Publisher Save 10.1002/ptr.7309

Abstract

Quercetin, widely distributed in fruits and vegetables, is a flavonoid known for its antioxidant, antiviral, antimicrobial, and antiinflammatory properties. Several studies highlight the potential use of quercetin as an antiviral, due to its ability to inhibit the initial stages of virus infection, to be able to interact with proteases important for viral replication, and to reduce inflammation caused by infection. Quercetin could also be useful in combination with other drugs to potentially enhance the effects or synergistically interact with them, in order to reduce their side effects and related toxicity. Since there is no comprehensive compilation about antiviral activities of quercetin and derivates, the aim of this review is providing a summary of their antiviral activities on a set of human viral infections along with mechanisms of action. Thus, the following family of viruses are examined: Flaviviridae, Herpesviridae, Orthomyxoviridae, Coronaviridae, Hepadnaviridae, Retroviridae, Picornaviridae, Pneumoviridae, and Filoviridae.

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Details

Published: Oct 28, 2021
Vol/Issue: 36(1)
Pages: 266-278
License: View

Authors

A

Amalia Di Petrillo

Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy

G

Germano Orrù

Department of Surgical Science University of Cagliari Cagliari Italy

A

Antonella Fais

Department of Life and Environmental Sciences University of Cagliari Cagliari Italy

M

Massimo C. Fantini

Department of Medical Sciences and Public Health University of Cagliari Cagliari Italy

Cite This Article

Amalia Di Petrillo, Germano Orrù, Antonella Fais, et al. (2021). Quercetin and its derivates as antiviral potentials: A comprehensive review. Phytotherapy Research, 36(1), 266-278. https://doi.org/10.1002/ptr.7309

Quercetin and its derivates as antiviral potentials: A comprehensive review

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