Remission duration: An example of interval‐censored observations

Gerta Rücker; Dorle Messerer

doi:10.1002/sim.4780071106

journal article Nov 01, 1988

Remission duration: An example of interval‐censored observations

Gerta Rücker

Dorle Messerer

Statistics in Medicine Vol. 7 No. 11 pp. 1139-1145 · Wiley

View at Publisher Save 10.1002/sim.4780071106

Abstract

AbstractRemission duration data from two observational studies, the German ALL/AUL study on acute lymphoblastic and acute undifferentiated leukaemia and the Kiel Lymphoma Study, are used to demonstrate the adequacy of an interval‐censoring approach. The Turnbull estimator is contrasted with the conventionally used Kaplan—Meier estimator. In addition, a parametric model is used for estimation or simulation of the delay times of complete remission diagnosis and relapse diagnosis. Two possible consequences of the conventional approach are discussed: biased estimation (for example, overestimation of remission duration), and underestimation of the true error variance, which may lead to false positive results. On the other hand, the applicability of the interval‐censoring approach is doubtful when the censoring mechanism (examination pattern, patient's behaviour) is confounded with the endpoints.

Topics

No keywords indexed for this article. Browse by subject →

References

11

[1]

Warr D. "Influence of measurement error on assessment of response to anticancer chemotherapy: Proposal for new criteria of tumor response" Journal of Clinical Oncology (1984) 10.1200/jco.1984.2.9.1040

[2]

Perry D. J. "Letter to the Editor" Journal of Clinical Oncology (1985)

[3]

Tannock I. "Reply" Journal of Clinical Oncology (1985)

[4]

10.2307/2530698

[5]

Turnbull B. W. "The empirical distribution function with arbitrarily grouped, censored and truncated data" Journal of the Royal Statistical Society, Series B (1976) 10.1111/j.2517-6161.1976.tb01597.x

[6]

Nonparametric Estimation from Incomplete Observations

E. L. Kaplan, Paul Meier

Journal of the American Statistical Association 10.1080/01621459.1958.10501452

[7]

Miller R. G. (1981)

[8]

Cox D. R. (1984)

[9]

Hoelzer D. "Intensified therapy in acute lymphoblastic and acute undifferentiated leukemia in adults" Blood (1984) 10.1182/blood.v64.1.38.38

[10]

10.1002/hon.2900020306

[11]

Grüger J. ‘Nichtparametrische Analyse sporadisch beobachtbarer Krankheitsverlaufsdaten’ PhD thesis Dortmund 1986.

Metrics

49

Citations

11

References

Details

Published: Nov 01, 1988
Vol/Issue: 7(11)
Pages: 1139-1145
License: View

Authors

G

Gerta Rücker

Department of Rehabilitative and Preventative Sports Medicine, University of Freiburg, Hugstetter Str. 55, D-79106 Freiburg

D

Dorle Messerer

Cite This Article

Gerta Rücker, Dorle Messerer (1988). Remission duration: An example of interval‐censored observations. Statistics in Medicine, 7(11), 1139-1145. https://doi.org/10.1002/sim.4780071106

Remission duration: An example of interval‐censored observations

You May Also Like