Pooled‐testing procedures for screening high volume clinical specimens in heterogeneous populations

Christopher R. Bilder; Joshua M. Tebbs

doi:10.1002/sim.5334

journal article Mar 13, 2012

Pooled‐testing procedures for screening high volume clinical specimens in heterogeneous populations

Christopher R. Bilder Joshua M. Tebbs

Statistics in Medicine Vol. 31 No. 27 pp. 3261-3268 · Wiley

View at Publisher Save 10.1002/sim.5334

Abstract

Pooled testing is a procedure commonly used to reduce the cost of screening a large number of individuals for infectious diseases. In its simplest form, pooled testing works by compositing a set of individual specimens (e.g., blood or urine) into a common pool. If the pool tests negative, all individuals within it are diagnosed as negative. If the pool tests positive, retesting is needed to decode the positive individuals from the negative individuals. Traditionally, pooled testing has assumed that each individual has the same probability of being positive. However, this assumption is often unrealistic, especially when known risk factors can be used to measure distinct probabilities of positivity for each individual. In this paper, we investigate new pooled‐testing algorithms that exploit the heterogeneity among individual probabilities and subsequently reduce the total number of tests needed, while maintaining accuracy levels similar to standard algorithms that do not account for heterogeneity. We apply these algorithms to data from the Infertility Prevention Project, a nationally implemented program supported by the Centers for Disease Control and Prevention. Copyright © 2012 John Wiley & Sons, Ltd.

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Metrics

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Citations

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References

Details

Published: Mar 13, 2012
Vol/Issue: 31(27)
Pages: 3261-3268
License: View

Authors

C

Christopher R. Bilder

Department of Statistics University of Nebraska—Lincoln Lincoln NE 68583 U.S.A.

J

Joshua M. Tebbs

Department of Statistics University of South Carolina Columbia SC 29208 U.S.A.

Funding

National Institutes of Health Award: R01 AI067373

Cite This Article

Christopher R. Bilder, Joshua M. Tebbs (2012). Pooled‐testing procedures for screening high volume clinical specimens in heterogeneous populations. Statistics in Medicine, 31(27), 3261-3268. https://doi.org/10.1002/sim.5334

Pooled‐testing procedures for screening high volume clinical specimens in heterogeneous populations

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