Increase of GAP‐43 in the rat cerebellum following unilateral striatal 6‐OHDA lesion

Milka Perović; Aleksandra Mladenovic; Ljubisav Rakić; Sabera Ruždijić; Selma Kanazir

doi:10.1002/syn.20142

journal article Mar 11, 2005

Increase of GAP‐43 in the rat cerebellum following unilateral striatal 6‐OHDA lesion

Milka Perović Aleksandra Mladenovic Ljubisav Rakić Sabera Ruždijić Selma Kanazir

Synapse Vol. 56 No. 3 pp. 170-174 · Wiley

View at Publisher Save 10.1002/syn.20142

Abstract

AbstractIn order to further characterize synaptic alterations following a severe lesion of the nigrostriatal system, the expression of synaptic marker proteins, synaptophysin and growth‐associated protein‐43 (GAP‐43), was examined in various brain regions of 6‐hydroxydopamine (6‐OHDA)‐treated rats, an animal model of Parkinson's disease. Unilateral nigrostriatal lesioning induced an increase in synaptophysin protein levels by 68% and 106% in the sensorimotor cortex and striatum, respectively, while changes in the level of GAP‐43 were not observed. In contrast, 6‐OHDA induced a 73% increase in the level of GAP‐43 protein in the cerebellum. This increase was also confirmed with immunohistochemistry. The level of synaptophysin in the cerebellum remained unchanged in response to the lesion. These results suggest that a neurotoxic lesion of the nigrostriatal pathway differentially affects the expression of the two synaptic proteins and that plasticity‐related changes in this model are not solely restricted to the nigrostriatal system. In addition, these results provide further evidence of the involvement of the cerebellum in the late response to a 6‐OHDA lesion. Synapse 56:170–174, 2005. © 2005 Wiley‐Liss, Inc.

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Details

Published: Mar 11, 2005
Vol/Issue: 56(3)
Pages: 170-174
License: View

Authors

M

Milka Perović

A

Aleksandra Mladenovic

Department of Neurobiology, Institute for Biological Research, University of Belgrade, 11000 Belgrade, Serbia

Cite This Article

Milka Perović, Aleksandra Mladenovic, Ljubisav Rakić, et al. (2005). Increase of GAP‐43 in the rat cerebellum following unilateral striatal 6‐OHDA lesion. Synapse, 56(3), 170-174. https://doi.org/10.1002/syn.20142

Increase of GAP‐43 in the rat cerebellum following unilateral striatal 6‐OHDA lesion

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