Cryptotanshinone protects against oxidative stress in the paraquat‐induced Parkinson's disease model

Jui‐Ming Sun; Surbhi Agarwal; Tushar Dnyaneshwar Desai; Da‐Tong Ju; Yung‐Ming Chang; Shih‐Chieh Liao; Tsung‐Jung Ho; Yu‐Lan Yeh; Wei‐Wen Kuo; Yu‐Jung Lin; Chih‐Yang Huang

doi:10.1002/tox.23660

journal article Sep 20, 2022

Cryptotanshinone protects against oxidative stress in the paraquat‐induced Parkinson's disease model

Jui‐Ming Sun Surbhi Agarwal Tushar Dnyaneshwar Desai Da‐Tong Ju Yung‐Ming Chang Shih‐Chieh Liao Tsung‐Jung Ho Yu‐Lan Yeh Wei‐Wen Kuo

Yu‐Jung Lin

Chih‐Yang Huang

Environmental Toxicology Vol. 38 No. 1 pp. 39-48 · Wiley

View at Publisher Save 10.1002/tox.23660

Abstract

AbstractParkinson's disease (PD) is a common neurodegenerative disorder associated with striatal dopaminergic neuronal loss in the Substantia nigra. Oxidative stress plays a significant role in several neurodegenerative diseases. Paraquat (PQ) is considered a potential neurotoxin that affects the brain leading to the death of dopaminergic neurons mimicking the PD phenotype. Various scientific reports have proven that cryptotanshinone possesses antioxidant and anti‐inflammatory properties. We hypothesized that cryptotanshinone could extend its neuroprotective activity by exerting antioxidant effects. This study was designed to evaluate the effects of cryptotanshinone in both cellular and animal models of PQ‐induced PD. Annexin V‐PI double staining and immunoblotting were used to detect apoptosis and oxidative stress proteins, respectively. Reactive oxygen species kits were used to evaluate oxidative stress in cells. For in vivo studies, 18 B6 mice were divided into three groups. The rotarod data revealed the motor function and immunostaining showed the survival of TH+ neurons in SNpc region. Our study showed that cryptotanshinone attenuated paraquat‐induced oxidative stress by upregulating anti‐oxidant markers in vitro, and restored behavioral deficits and survival of dopaminergic neurons in vivo, demonstrating its therapeutic potential.

Topics

No keywords indexed for this article. Browse by subject →

References

48

[1]

10.1016/j.amjmed.2019.03.001

[2]

10.1136/jnnp.2007.131045

[3]

10.3233/jpd-181474

[4]

10.1016/s1474-4422(05)70285-4

[5]

10.3390/nu12061707

[6]

10.1002/tox.23433

[7]

10.1002/tox.21943

[8]

10.3233/jpd-130230

[9]

10.1007/s11064-008-9656-2

[10]

10.1016/j.brainres.2007.06.046

[11]

10.3389/fncel.2020.581191

[12]

10.1002/tox.23001

[13]

10.1038/cdd.2009.217

[14]

10.1007/s11064-010-0163-x

[15]

10.1152/ajpcell.00283.2008

[16]

10.1016/j.mam.2011.10.006

[17]

10.1016/j.fitote.2020.104633

[18]

10.1016/j.biopha.2021.111332

[19]

10.1016/j.phrs.2017.11.018

[20]

10.1002/tox.23360

[21]

10.1002/tox.23307

[22]

10.1002/tox.23094

[23]

10.1111/jfbc.12902

[24]

10.1111/jfbc.13666

[25]

10.1186/s12986-020-0432-x

[26]

10.1002/tox.23449

[27]

10.1016/j.pneurobio.2013.04.004

[28]

10.1016/s0165-0270(98)00078-8

[29]

10.1046/j.1440-1789.1999.00196.x

[30]

10.3233/rnn-201070

[31]

10.3109/13880209.2015.1027408

[32]

10.3390/molecules25163602

[33]

10.1002/tox.22723

[34]

10.1074/jbc.m708451200

[35]

10.2174/138920007780655441

[36]

10.1007/s11064-011-0652-6

[37]

10.1186/1471-2202-10-88

[38]

10.1074/jbc.m700827200

[39]

10.1016/j.redox.2020.101606

[40]

10.1111/bcpt.13091

[41]

10.1016/j.freeradbiomed.2013.02.008

[42]

10.1016/j.bbamcr.2018.02.010

[43]

10.1016/j.bcp.2021.114719

[44]

Wu H "Erythropoietin suppresses d‐galactose‐induced aging of rats via the PI3K/Akt/Nrf2‐ARE pathway" Int J Clin Exp Pathol (2018)

[45]

10.1111/j.1742-4658.2012.08491.x

[46]

10.1177/1759091418777438

[47]

10.2174/187152712800792785

[48]

10.1038/labinvest.2015.161

Metrics

11

Citations

48

References

Details

Published: Sep 20, 2022
Vol/Issue: 38(1)
Pages: 39-48
License: View

Authors

J

Jui‐Ming Sun

Section of Neurosurgery, Department of Surgery Chia‐Yi Christian Hospital Chia‐Yi City Taiwan; Department of Biotechnology Asia University Taichung City Taiwan

S

Surbhi Agarwal

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan

T

Tushar Dnyaneshwar Desai

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan

D

Da‐Tong Ju

Department of Neurological Surgery, Tri‐Service General Hospital National Defense Medical Center Taipei Taiwan

Y

Yung‐Ming Chang

The School of Chinese Medicine for Post‐Baccalaureate I‐Shou University Kaohsiung Taiwan; Chinese Medicine Department, E‐DA Hospital Kaohsiung Taiwan; 1PT Biotechnology Co., Ltd. Taichung Taiwan

S

Shih‐Chieh Liao

Department of Social Medicine, School of Medicine China Medical University Taichung Taiwan

T

Tsung‐Jung Ho

Department of Chinese Medicine, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan; School of Post‐Baccalaureate Chinese Medicine, College of Medicine Tzu Chi University Hualien Taiwan

Y

Yu‐Lan Yeh

Department of Pathology Changhua Christian Hospital Changhua Taiwan; Department of Medical Technology Jen‐Teh Junior College of Medicine, Nursing and Management Miaoli Taiwan

W

Wei‐Wen Kuo

Department of Biological Science and Technology China Medical University Taichung Taiwan

Y

Yu‐Jung Lin

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan

C

Chih‐Yang Huang

Cardiovascular and Mitochondrial Related Disease Research Center, Hualien Tzu Chi Hospital Buddhist Tzu Chi Medical Foundation Hualien Taiwan; Department of Biological Science and Technology Asia University Taichung Taiwan; Center of General Education, Buddhist Tzu Chi Medical Foundation Tzu Chi University of Science and Technology Hualien Taiwan; Department of Medical Research, China Medical University Hospital China Medical University Taichung Taiwan; Graduate Institute of Biomedical Sciences China Medical University Taichung Taiwan

Funding

China Medical University, Taiwan Award: CMU108‐MF‐64

Asia University Award: CMU106‐ASIA‐02

Buddhist Tzu Chi Medical Foundation Award: IMAR110‐01‐11

Cite This Article

Jui‐Ming Sun, Surbhi Agarwal, Tushar Dnyaneshwar Desai, et al. (2022). Cryptotanshinone protects against oxidative stress in the paraquat‐induced Parkinson's disease model. Environmental Toxicology, 38(1), 39-48. https://doi.org/10.1002/tox.23660

Cryptotanshinone protects against oxidative stress in the paraquat‐induced Parkinson's disease model

You May Also Like