Muscle ATP loss and lactate accumulation at different work intensities in the exercising Thoroughbred horse

Roger C. Harris; David J. Marlin; David H. Snow; R. Angus Harkness

doi:10.1007/bf00571546

journal article Jan 01, 1991

Muscle ATP loss and lactate accumulation at different work intensities in the exercising Thoroughbred horse

Roger C. Harris David J. Marlin David H. Snow R. Angus Harkness

European Journal of Applied Physiology and Occupational Physiology Vol. 62 No. 4 pp. 235-244 · Springer Science and Business Media LLC

View at Publisher Save 10.1007/bf00571546

Topics

No keywords indexed for this article. Browse by subject →

References

39

[1]

Beaver WL, Wasserman K, Whipp BJ (1985) Improved detection of lactate threshold during exercise using a log-log transformation. J Appl Physiol 59:1936?1940 10.1152/jappl.1985.59.6.1936

[2]

Bergstrom J (1962) Muscle electrolytes in man. Determined by neutron activation analyses on needle biopsy specimens. A study on normal subjects, kidney patients and patients with chronic diarrhoea. Scand J Clin Lab Invest 14, Suppl 68

[3]

Boobis LH, Williams C, Wooton SA (1983) Influence of sprint training on muscle metabolism during brief maximal exercise in man. J Physiol (Loud) 342:36?37

[4]

Brooke MH, Kaiser KK (1970) The myosin adenosine triphosphatase systems: the nature of their pH lability and sulfhydryl dependence. J Histochem Cytochem 18:670?672 10.1177/18.9.670

[5]

Buono MJ, Clancy TR, Cook JR (1984) Blood lactate and ammonium ion accumulation during graded exercise in humans. J Appl Physiol 57:135?139 10.1152/jappl.1984.57.1.135

[6]

Coakley JH, Wagenmakers AJM, Edwards RHT (1989) Excessive ammonia production during cycle ergometry in McArdle's disease. Clin Sci [Suppl 25] 76:49

[7]

Dudley GA, Terjung RL (1985) Influence of acidosis on AMP deaminase activity in contracting fast-twitch muscle. Am J Physiol 248:C43-C50 10.1152/ajpcell.1985.248.1.c43

[8]

Ellington WR (1989) Phosphocreatine represents a thermodynamic and functional improvement over other muscle phosphagens. J Exp Biol 143:177?194 10.1242/jeb.143.1.177

[9]

Funk C, Clark A, Connett RJ (1989) How phosphocreatine buffers cyclic changes in ATP demand in working muscle. In: Rakusan K, Biro GP, Goldstick TK, Turek Z (eds) Oxygen transport to tissue XI. Plenum press, New York

[10]

Goodman MN, Lowenstein JM (1977) The purine nucleotide cycle: studies of ammonia production by skeletal muscle in situ and in perfused preparation. J Biol Chem 252:5054?5060 10.1016/s0021-9258(17)40157-8

[11]

Harkness RA (1988) Hypoxanthine, xanthine and uridine in body fluids, indicators of ATP depletion. J Chromatogr 428:255?278 10.1016/s0378-4347(00)83873-6

[12]

Harkness RA, McCreanor GM, Watts RWE (1988) Lesch-Nyhan syndrome and its pathogenesis: purine concentrations in plasma and. urine with metabolite profiles in CSF. J Inherited Metab Dis 11:239?252 10.1007/bf01800365

[13]

Harris RC, Hultman E (1985) Adenine nucleotide depletion in human muscle in response to intermittent stimulation in situ. J Physiol (Lond) 365:73

[14]

Harris RC, Hultman E, Nordesjo LO (1974) Glycogen, glycolytic intermediates and high energy phosphates in biopsy samples of musculus quadriceps femoris of man at rest. Methods and variance of values. Scand J Clin Lab Invest 33:109?120 10.3109/00365517409082477

[15]

Harris RC, Sahlin K, Hultman E (1977) Phosphagen and lactate contents of m quadriceps femoris of man after exercise. J Appl Physiol 43:852?857 10.1152/jappl.1977.43.5.852

[16]

Harris RC, Marlin DJ, Snow DH (1987a) Metabolic response to maximal exercise of 800 and 2000 m in the thoroughbred horse. J Appl Physiol 63:12?19 10.1152/jappl.1987.63.1.12

[17]

Harris RC, Harman J, Marlin DJ, Snow DH (1987b) Acute changes in the water content and density of blood and plasma in the thoroughbred horse during maximal exercise: relevance to the calculation of metabolite concentrations in these tissues and in muscle. In: Gillespie JR, Robinson NE (eds) Equine exercise physiology 2 ICEEP Publications, California, pp 464?475

[18]

Hultman E, Sjoholm H (1983) Energy metabolism and contraction force of human skeletal muscle in situ during electrical stimulation. J Physiol (Lond) 345:525?532 10.1113/jphysiol.1983.sp014994

[19]

Hultman E, Bergstrom J, McLennon-Anderson N (1967) Breakdown and resynthesis of phosphorylcreatine and adenosine triphosphate in connection with muscular work in man. Scand J Clin Lab Invest 19:56?66 10.3109/00365516709093481

[20]

Hultman E, Spriet LL, Soderlund K (1987) Energy metabolism and fatigue in working muscle. In: Macleod D, Maughan R, Nimmo M, Reilly T, Williams C (eds) Exercise, benefits, limits and adaptations. Spon, London, pp 63?84

[21]

Keenan DM (1978) Changes of plasma uric acid levels in horses after galloping. Res Vet Sci 25:127?128 10.1016/s0034-5288(18)33029-7

[22]

Ketai LH, Simon RH, Kreit JW, Grum CM (1987) Plasma hypoxanthine and exercise. Am Rev Respir Dis 136:98?101 10.1164/ajrccm/136.1.98

[23]

Marlin DJ, Harris RC, Gash SR, Snow DH (1989) Carnosine content of the middle gluteal muscle in thoroughbred horses with relation to age, sex and training. Comp Biochem Physiol [A] 93:629?632 10.1016/0300-9629(89)90023-6

[24]

McCreanor GM, Harkness RA (1987) Hypoxanthine output is increased by ATP use in man. Biochem Soc Trans 15:1060 10.1042/bst0151060

[25]

Meyer RA, Dudley GA, Terjung RL (1980) Ammonia and IMP in different skeletal muscle fibres after exercise in rats. J Appl Physiol 49:1037?1041 10.1152/jappl.1980.49.6.1037

[26]

Meyer RA, Brown TR, Kushmerick MJ (1984) Phosphorus nuclear magnetic resonance of slow twitch muscle. Am J Physiol 248:C279-C287 10.1152/ajpcell.1985.248.3.c279

[27]

Norman B, Sollevi A, Jansson E (1988) Increased IMP content in glycogen depleted muscle fibres during submaximal exercise in man. Acta Physiol Scand 133:97?100 10.1111/j.1748-1716.1988.tb08385.x

[28]

Park JH, Brown RL, Park CR, Cohn M, Chance B (1988) Energy metabolism of the untrained muscle of elite runners as observed by13P magnetic resonance spectroscopy: evidence suggesting a genetic endowment for endurance exercise. Proc Natl Acad Sci USA 85:8780?8784 10.1073/pnas.85.23.8780

[29]

Ronca-Testoni S, Raggi A, Ronca G (1970) Muscle AMP aminohydrolase. III. A comparative study on the regularity properties of skeletal muscle enzyme from various species. Biochem Biophys Acta 198:101?112 10.1016/0005-2744(70)90038-0

[30]

Sahlin K, Katz A (1988) Purine nucleotide metabolism. In: Poortmans JR (ed) Principles of exercise biochemistry. Karger, Basel

[31]

Sahlin K, Edstrom L, Sjoholm H, Hultman E (1981) Effects of lactic acid accumulation and ATP decrease on muscle tension and relaxation. Am J Physiol 240:C121-C126 10.1152/ajpcell.1981.240.3.c121

[32]

Setlow B, Lowenstein JM (1967) Adenylate deaminase. Purification and some regulatory properties of the enzyme from calf brain. J Biol Chem 242:607?615 10.1016/s0021-9258(18)96248-4

[33]

Siemankowski RF, White HD (1984) Kinetics of the interaction between actin, ADP and cardiac myosins. J Biol Chem 251:5045?5053 10.1016/s0021-9258(17)42953-x

[34]

Simmonds RJ, Harkness RA (1981) High performance liquid chromatographic methods for base and nucleoside analysis in extracellular fluids in cells. J Chromatogr 226:369?381 10.1016/s0378-4347(00)86071-5

[35]

Snow DH, Guy PS (1976) Percutaneous needle muscle biopsy in the horse. Equine Vet J 8:150?155 10.1111/j.2042-3306.1976.tb03327.x

[36]

Snow DH, Harris RC, Gash SP (1985) Metabolic response of equine muscle to intermittent maximal exercise. J Appl Physiol 58:1689?1697 10.1152/jappl.1985.58.5.1689

[37]

Sullivan T, Armstrong R (1978) Rat locomotory muscle fibre activity during trotting and galloping. J Appl Physiol 44:358?363 10.1152/jappl.1978.44.3.358

[38]

Ventura-Clapier R, Mekhfi H, Vassort G (1987) Role of creatine kinase in force development in chemically skinned rat cardiac muscle. J Gen Physiol 89:815?837 10.1085/jgp.89.5.815

[39]

Wheeler TJ, Lowenstein JM (1979) Adenylate deaminase from rat muscle. Regulation by purine nucleotides and orthophosphate in the presence of 150 mM KCl. J Biol Chem 254:8894?8999

Metrics

64

Citations

39

References

Details

Published: Jan 01, 1991
Vol/Issue: 62(4)
Pages: 235-244
License: View

Authors

Cite This Article

Roger C. Harris, David J. Marlin, David H. Snow, et al. (1991). Muscle ATP loss and lactate accumulation at different work intensities in the exercising Thoroughbred horse. European Journal of Applied Physiology and Occupational Physiology, 62(4), 235-244. https://doi.org/10.1007/bf00571546

Muscle ATP loss and lactate accumulation at different work intensities in the exercising Thoroughbred horse

You May Also Like