Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system

Norma M. Giusto; Marta E. Roque; Monica G. Ilincheta de Boschero

doi:10.1007/bf02535859

journal article Nov 01, 1992

Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system

Norma M. Giusto Marta E. Roque Monica G. Ilincheta de Boschero

Lipids Vol. 27 No. 11 pp. 835-839 · Wiley

View at Publisher Save 10.1007/bf02535859

Abstract

AbstractSphingomyelin (SPH) content and composition in different regions of the brain were analyzed in 2.5, 21.5 and 26.5‐month‐old rats. SPH content increased in the cerebral hemispheres, cerebellum and medulla oblongata plus pons as age increased. The highest SPH content was observed in 26.5‐month‐old rats, with values increasing by 1.74, 2.75 and 0.88‐fold, respectively, over 2.5‐month‐old rats. The SPH fatty acid composition of brains from aged rats was markedly different from that of adult rats. Between 2.5 and 26.5 months of age the monoenoic/saturated fatty acid ratio increased from 0.22, 0.30 and 0.54 to 0.54, 0.68 and 1.03 in cerebral hemispheres, cerebellum and medulla oblongata plus pons, respectively. The percentage and content of fatty acids longer than 22 carbon atoms esterified to SPH increased with age from 18, 26 and 44 to 48, 52 and 62 mole % in cerebral hemispheres, cerebellum and medulla oblongata plus pons in 26.5‐month‐old rats. In subcortical white matter from aged rats, monoenoic 22–26 carbon atom fatty acids increased more than the saturated ones in 21.5‐month‐old rats relative to 2.5‐month‐old rats.In vitro synthesis of SPH from [3H]choline and [3H]palmitic acid in cerebral cortex and cerebellum showed no significant differences between adult rats and those 21.5 months of age. In cerebellum and in cerebral cortex, [14C] serine incorporation increased in aged rats. The results suggest that aging induces increases in both SPH content and in the monoenoic/saturated fatty acid ratio. These increases are quantitatively different in all brain regions analyzed.

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Details

Published: Nov 01, 1992
Vol/Issue: 27(11)
Pages: 835-839
License: View

Authors

N

Norma M. Giusto

Institute de Investigaciones Bioquímicas Universidad Nacional del Sur y CONICET CC 857 Bahía Blanca 8000 Argentina

M

Marta E. Roque

Institute de Investigaciones Bioquímicas Universidad Nacional del Sur y CONICET CC 857 Bahía Blanca 8000 Argentina

M

Monica G. Ilincheta de Boschero

Institute de Investigaciones Bioquímicas Universidad Nacional del Sur y CONICET CC 857 Bahía Blanca 8000 Argentina

Cite This Article

Norma M. Giusto, Marta E. Roque, Monica G. Ilincheta de Boschero (1992). Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system. Lipids, 27(11), 835-839. https://doi.org/10.1007/bf02535859

Effects of aging on the content, composition and synthesis of sphingomyelin in the central nervous system

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