Synthesis of certain mercapto-and aminopyrimidine derivatives as potential antimicrobial agents

M. M. El-Kerdawy; H. M. Eisa; A. A. El-Emam; M. A. Massoud; M. N. Nasr

doi:10.1007/bf02857791

journal article Jun 01, 1990

Synthesis of certain mercapto-and aminopyrimidine derivatives as potential antimicrobial agents

M. M. El-Kerdawy H. M. Eisa A. A. El-Emam M. A. Massoud M. N. Nasr

Archives of Pharmacal Research Vol. 13 No. 2 pp. 142-146 · Springer Science and Business Media LLC

View at Publisher Save 10.1007/bf02857791

Topics

No keywords indexed for this article. Browse by subject →

References

19

[1]

Roth, B., Strelitz, J.Z. and Rauckman, B.S.: 2,4-Diamino-5-benzylpyrimidines and Analogues as Antibacterial Agents 2. C-Alkylation of Pyrimidines with Mannich Bases and Application to the Synthesis of Trimethoprim Analogues.J. Med. Chem. 23, 379 (1980). 10.1021/jm00178a007

[2]

Rauckman, B.S. and Roth, B.: 2,4-Diamino-5-benzylpyrimidines and Analogues as Antibacterial Agents 3. C-Benzylation of Aminopyrimidines with Phenolic Mannich Bases. Synthesis of 1-and 3-Deaza Analogues of Trimethoprim.J. Med. Chem. 23, 384 (1980). 10.1021/jm00178a008

[3]

Manius, G.J.:Analytical Profiles of Drug Substances (Florey, K., Ed.), Vol. 7, Academic Press, New York, p. 445 (1978).

[4]

Waysek, E.H. and Johnson, J.H.:Analytical Profiles of Drug Substance (Florey, K., Ed.), Vol. 5, Academic Press, New York, p. 115 (1976).

[5]

Undheim, K. and Gacek, M.: Some Derivatives of 5-Fluoropyrimidine.Acta Chem. Scand. 23, 294 (1969). 10.3891/acta.chem.scand.23-0294

[6]

Kreutzberger, A., Sellheim, M. and Rose, U.: 2-Cyanopyrimidines and 2-Chloro-s-triazines as Potential Antiviral Agents. Proc. 8th. Int. Symposium on Medicinal Chemistry, Vol. 1, Swedish Pharmaceutical Press, Stockholm, p. 234 (1984).

[7]

Hirata, M., Kobayashi, T. and Naito, T.: 3′-Aminocytidines.Japan Pat. 69,27,895.Chem. Abstr. 72, 44072r (1970).

[8]

Hamamura, E.K., Prystasz, M., Verheyden, J.P.H. and Moffatt, J.G.: Reaction of 2-Acyloxyisobutyryl Halides with Nucleosides 6. Synthesis and Biological Evaluation of Some 3′-Acyl Derivatives of 2,2′-Anhydro-1-(β-D-arabinofuranosyl)-cytosine Hydrochloride.J. Med. Chem. 19, 654 (1976). 10.1021/jm00227a016

[9]

Hamamura, E.K., Prystasz, M., Verheyden, J.P.H. and Moffatt, J.G.: Reaction of 2-Acyloxyisobutyryl Halides with Nucleosides 7. Synthesis and Biological Evaluation of Some 2,2′-anhydro-1-(3′,5′-di-O-acyl-β-D-arabinofuranosyl) cytosine Hydrochloride.J. Med. Chem. 19, 663 (1976). 10.1021/jm00227a017

[10]

Shen, T. and Ruyle, W.V.: 1-(β-D-Arabinofuranosyl)-2-thiopyrimidines. U.S. Pat. 3,463,850.Chem. Abstr. 72, 44075u (1970).

[11]

Budesinsky, Z., Prikryl, J. and Jelinek, V.: 2-Hydroxy-5-fluoropyrimidines.Czech. Pat. 122, 776.Chem. Abstr. 68, 29719f (1968).

[12]

Heidelberger, C. and Duschinsky, R.: 5-Fluorouracil. U.S. Pat. 2,802,005.Chem. Abstr. 52, 2100e (1958).

[13]

Heidelberger, C., Chaudhuri, N.K., Danneberg, P., Mooren, D., Griesbach, L., Duschinsky, R., Schinitzer, R.J., Pleven, E. and Scheiner, J.: Fluorinated Pyrimidines, a New Class of Tumour-inhibitory Compounds.Nature 179, 663 (1957). 10.1038/179663a0

[14]

Elkouni, M., Niedzwicki, J., Lee, K., Senft, A. and Cha, S.: Enzymes of Pyrimidine Metabolism in Schistosoma mansoni.Fed. Proc. 42, 2207 (1983).

[15]

Sirawarporn, W., Sertsrivanich, R., Booth, R.G., Hansch, C., Neal, R.A. and Santi, D.: Selective Inhibition of Leishmania Dihydrofolate Reductase and Leishmania Growth by 5-Benzyl-2, 4-diaminopyrimidines.Mol. Biochem. Parasitol. 31, 79 (1988). 10.1016/0166-6851(88)90147-8

[16]

El-Kerdawy, M.M., El-Emam, A.A., El-Subbagh, H.I. and Abushanab, E.: Synthesis of Certain Substituted Pyrimidines as Potential Schistosomicidal Agents.J. Heterocycl. Chem. 26, 913 (1989). 10.1002/jhet.5570260406

[17]

Mitter, P.C. and Bardhan, J.C.: Condensation of Amidnes with Ethoxymethylene Derivatives of β-Ketonic Esters and of β-Diketones.J. Chem. Soc. 2179 (1923). 10.1039/ct9232302179

[18]

Kim, D.H. and Santilli, A.A.: Pyrrolo [2,3-d] pyrimidines 1. 5-Hydroxypyrrolo [2,3-d] pyrimidines.J. Heterocycl. Chem. 6, 810 (1969).

[19]

Blain, J. Linnert, e. and Traunat, J.:Manual of Clinical Micrrobiology. American Society of Microbiology, Bethesda, USA, p. 300 (1970).

Metrics

3

Citations

19

References

Details

Published: Jun 01, 1990
Vol/Issue: 13(2)
Pages: 142-146
License: View

Authors

Cite This Article

M. M. El-Kerdawy, H. M. Eisa, A. A. El-Emam, et al. (1990). Synthesis of certain mercapto-and aminopyrimidine derivatives as potential antimicrobial agents. Archives of Pharmacal Research, 13(2), 142-146. https://doi.org/10.1007/bf02857791

Synthesis of certain mercapto-and aminopyrimidine derivatives as potential antimicrobial agents

You May Also Like