Urinary incontinence and quality of life: a systematic review and meta-analysis

Damiano Pizzol; Jacopo Demurtas; Stefano Celotto; Stefania Maggi; Lee Smith; Gabriele Angiolelli; Mike Trott; Lin Yang; Nicola Veronese

doi:10.1007/s40520-020-01712-y

journal article Open Access Sep 22, 2020

Urinary incontinence and quality of life: a systematic review and meta-analysis

Damiano Pizzol Jacopo Demurtas Stefano Celotto Stefania Maggi

Lee Smith

Gabriele Angiolelli Mike Trott Lin Yang

Nicola Veronese

Aging Clinical and Experimental Research Vol. 33 No. 1 pp. 25-35 · Springer Science and Business Media LLC

View at Publisher Save 10.1007/s40520-020-01712-y

Abstract

AbstractBackgroundUrinary incontinence (UI) and low quality of life (QoL) are two common conditions. Some recent literature proposed that these two entities can be associated. However, no attempt was made to collate this literature. Therefore, the aim of this study was to conduct a systematic review and meta-analysis of existing data to estimate the strength of the association between UI and QoL.MethodsAn electronic search of major databases up to 18th April 2020 was carried out. Meta-analysis of cross-sectional and case–control studies comparing mean values in QoL between patients with UI and controls was performed, reporting random-effects standardized mean differences (SMDs) ± 95% confidence intervals (CIs) as the effect size. Heterogeneity was assessed with theI2.ResultsOut of 8279 articles initially screened, 23 were finally included for a total of 24,983 participants, mainly women. The mean age was ≥ 50 years in 12/23 studies. UI was significantly associated with poor QoL as assessed by the short-form 36 (SF-36) total score (n = 6 studies; UI: 473 vs. 2971 controls; SMD = − 0.89; 95% CI − 1.3 to − 0.42;I2 = 93.5) and by the sub-scales of SF-36 and 5/8 of the domains included in the SF-36. Similar results were found using other QoL tools. The risk of bias of the studies included was generally high.ConclusionsUI is associated with a poor QoL, with a strong level of certainty. This work, however, mainly based on cross-sectional and case–control studies, highlights the necessity of future longitudinal studies for better understanding the importance of UI on QoL.

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Details

Published: Sep 22, 2020
Vol/Issue: 33(1)
Pages: 25-35
License: View

Authors

Czech Academy of Sciences, Institute of Inorganic Chemistry

N

Nicola Veronese

Funding

Santex SPA

Cite This Article

Damiano Pizzol, Jacopo Demurtas, Stefano Celotto, et al. (2020). Urinary incontinence and quality of life: a systematic review and meta-analysis. Aging Clinical and Experimental Research, 33(1), 25-35. https://doi.org/10.1007/s40520-020-01712-y

Urinary incontinence and quality of life: a systematic review and meta-analysis

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