Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling

Pernille M. Madsen; Haritha L. Desu; Juan Pablo de Rivero Vaccari; Yoleinny Florimon; Ditte G. Ellman; Robert W. Keane; Bettina H. Clausen; Kate L. Lambertsen; Roberta Brambilla

doi:10.1016/j.bbi.2019.11.017

journal article Feb 01, 2020

Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling

Pernille M. Madsen Haritha L. Desu Juan Pablo de Rivero Vaccari

Yoleinny Florimon Ditte G. Ellman Robert W. Keane Bettina H. Clausen Kate L. Lambertsen Roberta Brambilla

Brain, Behavior, and Immunity Vol. 84 pp. 132-146 · Elsevier BV

View at Publisher Save 10.1016/j.bbi.2019.11.017

Topics

No keywords indexed for this article. Browse by subject →

References

62

[1]

Aboul-Enein "Preferential loss of myelin-associated glycoprotein reflects hypoxia-like white matter damage in stroke and inflammatory brain diseases" J. Neuropathol. Exp. Neurol. (2003) 10.1093/jnen/62.1.25

[2]

Argaw "IL-1beta regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program" J. Immunol. (2006) 10.4049/jimmunol.177.8.5574

[3]

Arnett "TNF alpha promotes proliferation of oligodendrocyte progenitors and remyelination" Nat. Neurosci. (2001) 10.1038/nn738

[4]

Balabanov "Interferon-gamma-oligodendrocyte interactions in the regulation of experimental autoimmune encephalomyelitis" J. Neurosci. (2007) 10.1523/jneurosci.4689-06.2007

[5]

Black "A metalloproteinase disintegrin that releases tumour-necrosis factor-alpha from cells" Nature (1997) 10.1038/385729a0

[6]

Boven "Macrophage inflammatory protein-1alpha (MIP-1alpha), MIP-1beta, and RANTES mRNA semiquantification and protein expression in active demyelinating multiple sclerosis (MS) lesions" Clin. Exp. Immunol. (2000) 10.1046/j.1365-2249.2000.01334.x

[7]

Brambilla "The contribution of astrocytes to the neuroinflammatory response in multiple sclerosis and experimental autoimmune encephalomyelitis" Acta Neuropathol. (2019) 10.1007/s00401-019-01980-7

[8]

Brambilla "Inhibition of soluble tumour necrosis factor is therapeutic in experimental autoimmune encephalomyelitis and promotes axon preservation and remyelination" Brain (2011) 10.1093/brain/awr199

[9]

Constantinescu "Experimental autoimmune encephalomyelitis (EAE) as a model for multiple sclerosis (MS)" Br. J. Pharmacol. (2011) 10.1111/j.1476-5381.2011.01302.x

[10]

HIF1α and metabolic reprogramming in inflammation

Sarah E. Corcoran, Luke A.J. O’Neill

Journal of Clinical Investigation 2016 10.1172/jci84431

[11]

Dostert "The TNF family of ligands and receptors: communication modules in the immune system and beyond" Physiol. Rev. (2019) 10.1152/physrev.00045.2017

[12]

Du "MicroRNA miR-326 regulates TH-17 differentiation and is associated with the pathogenesis of multiple sclerosis" Nat. Immunol. (2009) 10.1038/ni.1798

[13]

Dumas "The inflammasome pyrin contributes to pertussis toxin-induced IL-1beta synthesis, neutrophil intravascular crawling and autoimmune encephalomyelitis" PLoS Pathog. (2014) 10.1371/journal.ppat.1004150

[14]

Disease-specific oligodendrocyte lineage cells arise in multiple sclerosis

Ana Mendanha Falcão, David Van Bruggen, Sueli Marques et al.

Nature Medicine 2018 10.1038/s41591-018-0236-y

[15]

Farez "Toll-like receptor 2 and poly(ADP-ribose) polymerase 1 promote central nervous system neuroinflammation in progressive EAE" Nat. Immunol. (2009) 10.1038/ni.1775

[16]

Freeman "Evolving concepts of gliogenesis: a look way back and ahead to the next 25 years" Neuron (2013) 10.1016/j.neuron.2013.10.034

[17]

Gao "Opposing Functions of Microglial and Macrophagic TNFR2 in the Pathogenesis of Experimental Autoimmune Encephalomyelitis" Cell Rep. (2017) 10.1016/j.celrep.2016.11.083

[18]

Gerhardt "Monocyte trafficking across the vessel wall" Cardiovasc. Res. (2015) 10.1093/cvr/cvv147

[19]

Grell "The transmembrane form of tumor necrosis factor is the prime activating ligand of the 80 kDa tumor necrosis factor receptor" Cell (1995) 10.1016/0092-8674(95)90192-2

[20]

Grell "The type 1 receptor (CD120a) is the high-affinity receptor for soluble tumor necrosis factor" Proc. Natl. Acad. Sci. U.S.A (1998) 10.1073/pnas.95.2.570

[21]

Gris "NLRP3 plays a critical role in the development of experimental autoimmune encephalomyelitis by mediating Th1 and Th17 responses" J. Immunol. (2010) 10.4049/jimmunol.0904145

[22]

Natural RNA circles function as efficient microRNA sponges

Thomas B. Hansen, Trine I. Jensen, Bettina H. Clausen et al.

Nature 2013 10.1038/nature11993

[23]

Hofman "Tumor necrosis factor identified in multiple sclerosis brain" J. Exp. Med. (1989) 10.1084/jem.170.2.607

[24]

Holtmann "Differential TNF-signaling in chronic inflammatory disorders" Curr. Mol. Med. (2004) 10.2174/1566524043360636

[25]

Honardoost "miR-326 and miR-26a, two potential markers for diagnosis of relapse and remission phases in patient with relapsing-remitting multiple sclerosis" Gene (2014) 10.1016/j.gene.2014.04.069

[26]

Imtiyaz "Hypoxia-inducible factors as essential regulators of inflammation" Curr. Top. Microbiol. Immunol. (2010)

[27]

Inoue "NLRP3 Inflammasome and MS/EAE" Autoimmune Dis. (2013)

[28]

Altered human oligodendrocyte heterogeneity in multiple sclerosis

Sarah Jäkel, Eneritz Agirre, Ana Mendanha Falcão et al.

Nature 2019 10.1038/s41586-019-0903-2

[29]

Jang "25-hydroxycholesterol contributes to cerebral inflammation of X-linked adrenoleukodystrophy through activation of the NLRP3 inflammasome" Nat. Commun. (2016) 10.1038/ncomms13129

[30]

Kang "Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells" Nat. Neurosci. (2013) 10.1038/nn.3505

[31]

Karim "Increase in chemokine CXCL1 by ERbeta ligand treatment is a key mediator in promoting axon myelination" Proc. Natl. Acad. Sci. U.S.A (2018) 10.1073/pnas.1721732115

[32]

Kemanetzoglou "CNS Demyelination with TNF-alpha Blockers" Curr. Neurol. Neurosci. Rep. (2017) 10.1007/s11910-017-0742-1

[33]

Kriegler "A novel form of TNF/cachectin is a cell surface cytotoxic transmembrane protein: ramifications for the complex physiology of TNF" Cell (1988) 10.1016/0092-8674(88)90486-2

[34]

Levesque "Myeloid cell transmigration across the CNS vasculature triggers IL-1beta-driven neuroinflammation during autoimmune encephalomyelitis in mice" J. Exp. Med. (2016) 10.1084/jem.20151437

[35]

Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2−ΔΔCT Method

Kenneth J. Livak, Thomas D. Schmittgen

Methods 2001 10.1006/meth.2001.1262

[36]

Lucchinetti "Heterogeneity of multiple sclerosis lesions: implications for the pathogenesis of demyelination" Ann. Neurol. (2000) 10.1002/1531-8249(200006)47:6<707::aid-ana3>3.0.co;2-q

[37]

Madsen "Genetic ablation of soluble tumor necrosis factor with preservation of membrane tumor necrosis factor is associated with neuroprotection after focal cerebral ischemia" J. Cereb. Blood Flow Metab. (2015)

[38]

Madsen "Oligodendroglial TNFR2 mediates membrane TNF-dependent repair in experimental autoimmune encephalomyelitis by promoting oligodendrocyte differentiation and remyelination" J. Neurosci. (2016) 10.1523/jneurosci.0211-16.2016

[39]

Madsen "Prolonged stimulation of a brainstem raphe region attenuates experimental autoimmune encephalomyelitis" Neuroscience (2017) 10.1016/j.neuroscience.2017.01.037

[40]

Identification of cell types producing RANTES, MIP-1α and MIP-1β in rat experimental autoimmune encephalomyelitis by in situ hybridization

Ryuji Miyagishi, Seiji Kikuchi, Chitoshi Takayama et al.

Journal of Neuroimmunology 1997 10.1016/s0165-5728(97)00040-4

[41]

Moreno "Conditional ablation of astroglial CCL2 suppresses CNS accumulation of M1 macrophages and preserves axons in mice with MOG peptide EAE" J. Neurosci. (2014) 10.1523/jneurosci.1137-14.2014

[42]

Moss "Cloning of a disintegrin metalloproteinase that processes precursor tumour-necrosis factor-alpha" Nature (1997) 10.1038/385733a0

[43]

Moyon "Demyelination causes adult CNS progenitors to revert to an immature state and express immune cues that support their migration" J. Neurosci. (2015) 10.1523/jneurosci.0849-14.2015

[44]

Olson "Microglia initiate central nervous system innate and adaptive immune responses through multiple TLRs" J. Immunol. (2004) 10.4049/jimmunol.173.6.3916

[45]

Omari "Neuroprotection and remyelination after autoimmune demyelination in mice that inducibly overexpress CXCL1" Am. J. Pathol. (2009) 10.2353/ajpath.2009.080350

[46]

Petkovic "Astrocyte-targeted production of interleukin-6 reduces astroglial and microglial activation in the cuprizone demyelination model: Implications for myelin clearance and oligodendrocyte maturation" Glia (2016) 10.1002/glia.23043

[47]

TNF and its receptors in the CNS: The essential, the desirable and the deleterious effects

L. Probert

Neuroscience 2015 10.1016/j.neuroscience.2015.06.038

[48]

Radu "An in vivo assay to test blood vessel permeability" J Vis Exp (2013) 10.3791/50062

[49]

Ransohoff "The anatomical and cellular basis of immune surveillance in the central nervous system" Nat. Rev. Immunol. (2012) 10.1038/nri3265

[50]

Ransohoff "Astrocyte expression of mRNA encoding cytokines IP-10 and JE/MCP-1 in experimental autoimmune encephalomyelitis" FASEB J. (1993) 10.1096/fasebj.7.6.8472896

Showing 50 of 62 references

Metrics

74

Citations

62

References

Details

Published: Feb 01, 2020
Vol/Issue: 84
Pages: 132-146
License: View

Authors

Juan Pablo de Rivero Vaccari

10The Miami Project to Cure Paralysis, Department of Neurological Surgery, University of Miami Miller School of Medicine, Miami, Florida.

Funding

NIH NINDS Award: 1RO1NS094522-01

Fonden til Lægevidenskabens Fremme

Danish Multiple Sclerosis Society

The Miami Project to Cure Paralysis

Foundation for Research in Neurology

Cite This Article

Pernille M. Madsen, Haritha L. Desu, Juan Pablo de Rivero Vaccari, et al. (2020). Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling. Brain, Behavior, and Immunity, 84, 132-146. https://doi.org/10.1016/j.bbi.2019.11.017

Oligodendrocytes modulate the immune-inflammatory response in EAE via TNFR2 signaling

You May Also Like